p53 and c-jun expression in urinary bladder transitional cell carcinoma: correlation with proliferating cell nuclear antigen (PCNA) histological grade and clinical stage

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dc.contributor.authorSkopelitou, A.en
dc.contributor.authorHadjiyannakis, M.en
dc.contributor.authorDimopoulos, D.en
dc.contributor.authorKamina, S.en
dc.contributor.authorKrikoni, O.en
dc.contributor.authorAlexopoulou, V.en
dc.contributor.authorRigas, C.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:00:19Z
dc.date.available2015-11-24T19:00:19Z
dc.identifier.issn0302-2838-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19509
dc.rightsDefault Licence-
dc.subjectAntibodies, Monoclonalen
dc.subjectBiopsyen
dc.subjectCarcinoma, Transitional Cell/chemistry/*genetics/mortality/pathologyen
dc.subjectCell Division/geneticsen
dc.subjectGene Expression Regulation, Neoplastic/*geneticsen
dc.subjectGenes, jun/geneticsen
dc.subjectGenes, p53/geneticsen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectNeoplasm Recurrence, Localen
dc.subjectProliferating Cell Nuclear Antigen/analysis/*biosynthesis/geneticsen
dc.subjectProto-Oncogene Proteins c-jun/analysis/*biosynthesis/geneticsen
dc.subjectSurvival Analysisen
dc.subjectTumor Suppressor Protein p53/analysis/*biosynthesis/geneticsen
dc.subjectUrinary Bladder Neoplasms/chemistry/*genetics/mortality/pathologyen
dc.titlep53 and c-jun expression in urinary bladder transitional cell carcinoma: correlation with proliferating cell nuclear antigen (PCNA) histological grade and clinical stageen
heal.abstractOBJECTIVE: To investigate p53 and c-jun oncoproteins and proliferating cell nuclear antigen (PCNA) in transitional cell urinary bladder carcinomas (TCCs) and to determine their relationships to tumour grade, stage and survival. MATERIALS AND METHODS: The expression of p53, c-jun and PCNA was studied using immunohistochemistry in formalin-fixed, paraffin-embedded tissues in a series of 110 TCCs. RESULTS: 58% of our cases were positive for p53 and 88% for c-jun. A statistically very significant correlation (p < 0.0001) was observed between p53 and c-jun (r = 0.781), p53 and PCNA (r = 0.772), c-jun and PCNA (r = 0.831) as well as between each of the two oncoproteins and the histological grade and clinical stage (p < 0.001). There was no correlation of either p53, PCNA or c-jun with clinical outcome in terms of patients survival. CONCLUSION: p53 and c-jun proteins' overexpression are strongly related to rapid tumour cell proliferation and hence with aggressive growth in urinary bladder TCC. PCNA score remains an important prognostic index in transitional cell carcinoma of the bladder.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9187909-
heal.journalNameEur Urolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1997-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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