Involvement of dysadherin and E-cadherin in the development of testicular tumours

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dc.contributor.authorBatistatou, A.en
dc.contributor.authorScopa, C. D.en
dc.contributor.authorRavazoula, P.en
dc.contributor.authorNakanishi, Y.en
dc.contributor.authorPeschos, D.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorHirohashi, S.en
dc.contributor.authorCharalabopoulos, K. A.en
dc.date.accessioned2015-11-24T19:09:00Z
dc.date.available2015-11-24T19:09:00Z
dc.identifier.issn0007-0920-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20633
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCadherins/*biosynthesis/physiologyen
dc.subjectCarcinoma, Embryonal/*genetics/*physiopathologyen
dc.subjectCell Adhesionen
dc.subjectGene Expression Profilingen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphoma, Non-Hodgkin/*genetics/*physiopathologyen
dc.subjectMaleen
dc.subjectMembrane Glycoproteins/*biosynthesis/physiologyen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Proteins/*biosynthesis/physiologyen
dc.subjectTesticular Neoplasms/*genetics/*physiopathologyen
dc.titleInvolvement of dysadherin and E-cadherin in the development of testicular tumoursen
heal.abstractTesticular neoplasms are comprised of a variety of histologically different forms, and their pathogenesis has not been elucidated. Dysadherin is a recently described cell membrane glycoprotein, which has an anticell-cell adhesion function and downregulates E-cadherin. In this study, we examined immunohistochemically the expression of E-cadherin and dysadherin in 120 testicular neoplasms (37 seminomas-26 classic, five spermatocytic and six anaplastic-, 45 embryonal carcinomas, 10 mixed germ cell tumours, two yolk sac tumours, 10 mature and eight immature teratomas and eight non-Hodgkin B-cell lymphomas), clinical stage I. The intensity, the expression pattern and the percentage of neoplastic cell staining was recorded and correlated with the histologic type and vascular/lymphatic invasion. Dysadherin was not expressed in non-neoplastic germ cells, neither in CIS/ITGCNU, but it was highly expressed in all types of germ cell tumours, that demonstrated either embryonic phenotype or somatic differentiation, in most terminally differentiated neoplasms, and in all lymphomas. Dysadherin expression did not correlate with vascular invasion. Increased dysadherin expression was correlated with aberrant E-cadherin expression in most tumours. In 17% of embryonal carcinomas colocalisation of dysadherin and membranous E-cadherin staining was noted. This is the first report on dysadherin expression and its association with E-cadherin in testicular tumours. Since dysadherin is not normally expressed in non-neoplastic testis, it is conceivable that it plays a role in the neoplastic transformation of germ cells. In testicular tumours, as in other neoplasms, dysadherin downregulates E-cadherin expression, at least in part.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1038/sj.bjc.6602880-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16333245-
heal.identifier.secondaryhttp://www.nature.com/bjc/journal/v93/n12/pdf/6602880a.pdf-
heal.journalNameBr J Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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