Thermodynamic and structural characterization of the macrochelates formed in the reactions of copper(II) and zinc(II) ions with peptides of histidine
| dc.contributor.author | Kallay, C. | en |
| dc.contributor.author | Varnagy, K. | en |
| dc.contributor.author | Malandrinos, G. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Sanna, D. | en |
| dc.contributor.author | Sovago, I. | en |
| dc.date.accessioned | 2015-11-24T16:51:31Z | |
| dc.date.available | 2015-11-24T16:51:31Z | |
| dc.identifier.issn | 0020-1693 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9744 | |
| dc.rights | Default Licence | - |
| dc.subject | histidine | en |
| dc.subject | sarcosine | en |
| dc.subject | peptides | en |
| dc.subject | macrochelate | en |
| dc.subject | copper(ii) | en |
| dc.subject | zinc(ii) | en |
| dc.subject | transition-metal-complexes | en |
| dc.subject | cysteine and/or histidine | en |
| dc.subject | l-proline residue | en |
| dc.subject | break-point | en |
| dc.subject | histone h2a | en |
| dc.subject | coordinating properties | en |
| dc.subject | solution equilibria | en |
| dc.subject | solution behavior | en |
| dc.subject | aqueous-solution | en |
| dc.subject | binding details | en |
| dc.title | Thermodynamic and structural characterization of the macrochelates formed in the reactions of copper(II) and zinc(II) ions with peptides of histidine | en |
| heal.abstract | Copper(II) complexes of the peptides Ac-HisSarHis-NH(2), Ac-HisSarHisSarHis-NH(2) and Ac-HisSarHisSarHisSarHis-NH(2) have been studied by potentiometric, UV-Vis, CD and EPR spectroscopic methods. Stability constants for the corresponding zinc(II) complexes have also been reported. The formation of M(II)-2N(im), M(II)-3N(im) and M(II)-4N(im) bonded macrochelates was suggested in the pH range 5-7. The macrochelates were, however, not stable enough to prevent metal ion hydrolysis in slightly alkaline solutions. In the case of copper(II) complexes, the metal ion promoted deprotonation and coordination of the amide groups of histidyl residues were also suggested. The stability constants of macrochelate complexes were compared to the literature data reported for the macrochelates of the other peptides of histidine. It was found that the thermodynamic stability of macrochelate species is largely influenced by the number and location of histidyl residues in the peptide backbone. The highest stability was obtained for the HXHYH-type sequences, while the distant arrangement of histidyl residues resulted in a significant reduction of the stability constants. (C) 2008 Elsevier B. V. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1016/j.ica.2008.01.022 | - |
| heal.identifier.secondary | <Go to ISI>://000262978000035 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0020169308000273/1-s2.0-S0020169308000273-main.pdf?_tid=129da1896ebe69e5a0583b8ae20573dc&acdnat=1333034566_aef42d314fadb39e4c9d607b14e19c77 | - |
| heal.journalName | Inorganica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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