Serum lipoprotein(a) concentrations and apolipoprotein(a) isoforms: association with the severity of clinical presentation in patients with coronary heart disease

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dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorKarabina, S. A.en
dc.contributor.authorTambaki, A. P.en
dc.contributor.authorGoudevenos, J. A.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorTsironis, L. D.en
dc.contributor.authorStroumbis, C. S.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorSideris, D. A.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:47:03Z
dc.date.available2015-11-24T16:47:03Z
dc.identifier.issn1350-6277-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9137
dc.rightsDefault Licence-
dc.subjectapolipoprotein (a)en
dc.subjectlow molecular weight isoformsen
dc.subjectlipoprotein(a)en
dc.subjectacute coronary syndromesen
dc.subjectcoronary heart diseaseen
dc.subjectmyocardial-infarctionen
dc.subjectartery diseaseen
dc.subjectplasma lipoprotein(a)en
dc.subjectlp(a) lipoproteinen
dc.subjectldl cholesterolen
dc.subjectrisken
dc.subjectplasminogenen
dc.subjectparticipantsen
dc.subjectpredictoren
dc.subjectanginaen
dc.titleSerum lipoprotein(a) concentrations and apolipoprotein(a) isoforms: association with the severity of clinical presentation in patients with coronary heart diseaseen
heal.abstractObjective The aim of this study was to investigate the possible associations between lipoprotein(a) [Lp(a)] concentrations or apolipoprotein(a) isoforms and the mode of clinical presentation of coronary heart disease (CHID) (acute thrombotic event or not). Methods A total of 131 CHD patients and 71 age- and gender-matched individuals without known CAD (free of symptoms of heart disease) were enrolled in the study. CHD patients were classified into patients with a history of an acute coronary syndrome (ACS, n=94) and patients with stable angina (SA, n=37). Lp(a) levels were measured with an ELISA method, whereas apolipoprotein(a) isoform analysis was performed (in all patients and 33 controls) by electrophoresis in 1.5% SDS-agarose gels followed by immunoblotting. Isoform size was expressed as the number of kringle 4 (K4) repeats. Results ACS patients had higher Lp(a) plasma levels [21.9 (0.8-84.1) mg/dl] and a greater proportion of elevated (greater than or equal to 30 mg/dl) Lp(a) concentrations (25.5%) compared with SA patients [9.2 (0.8-50.5) mg/dl, P < 0.01 and 10.8%, P < 0.05] and controls [8.0 (0.8-55.0) mg/dl, P < 0.01 and 11.2%, P < 0.05], while there were no differences between SA patients and controls. The median apolipoprotein(a)-isoform size was 26 K4. In 17 (10%) patients we could not detect any apolipoprotein(a) isoform bands by immunoblotting. ACS patients had a higher proportion of isoforms < 26 K4 (low molecular weight) than SA patients (56/85 vs. 12/33, P < 0.005) and controls (10/29, P < 0.005). Conclusions CAD patients with a history of ACS have higher Lp(a) plasma levels and a significantly higher proportion of low molecular weight apolipoprotein(a) isoforms compared with patients with SA or to controls. (C) 2001 Lippincott Williams & Wilkins.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000171905400011-
heal.journalNameJ Cardiovasc Risken
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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