Lack of association between carotid intima-media thickness and PAF-acetylhydrolase mass and activity in patients with primary hyperlipidemia

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dc.contributor.authorKiortsis, D. N.en
dc.contributor.authorTsouli, S.en
dc.contributor.authorLourida, E. S.en
dc.contributor.authorXydis, V.en
dc.contributor.authorArgyropoulou, M. I.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:40:56Z
dc.date.available2015-11-24T16:40:56Z
dc.identifier.issn0003-3197-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8335
dc.rightsDefault Licence-
dc.subjectplatelet-activating-factoren
dc.subjectcoronary-heart-diseaseen
dc.subjectcardiovascular risk-factorsen
dc.subjectarterial-wall thicknessen
dc.subjectlow-density-lipoproteinen
dc.subjectc-reactive proteinen
dc.subjectatherosclerosis risken
dc.subjectphospholipase a(2)en
dc.subjectinsulin-resistanceen
dc.subjectdiabetes-mellitusen
dc.titleLack of association between carotid intima-media thickness and PAF-acetylhydrolase mass and activity in patients with primary hyperlipidemiaen
heal.abstractCarotid intima media thickness (IMT), represents an important clinical indicator of early atherosclerosis. Human plasma platelet-activating factor acety1hydrolase (PAF-AH) is an enzyme primarily associated with low-density lipoprotein (LDL) while a small proportion of enzymatic activity is also associated with high-density lipoprotein (HDL). Plasma paraoxonase 1 (PON 1) is an esterase exclusively associated with HDL. The authors investigated the possible relationship between carotid IMT and the plasma levels of PAF-AH mass and activity as well as the PON 1 activity in hyperlipiclemic patients. One hundred unrelated patients with primary hyperlipidemia and 67 age- and sex-matched normolipidemic apparently healthy volunteers participated in the study. The PAF-AH activity in total plasma and in HDL-rich plasma (HDL-PAF-AH activity), the plasma PAF-AH mass, and the serum PON I activities toward paraoxon and phenyl acetate were determined. The plasma PAF-AH mass and activity were higher in hyperlipidemic patients compared to controls, whereas the HDL-PAF-AH activity, as well as the serum PON I activities were not significantly different between the studied groups. When hyperlipidemic patients were divided into 2 subgroups according to their IMT values (IMT < 0.7 mm and IMT >= 0.7 mm) patients with IMT >= 0.7 mm had significantly higher age, and serum triglycericle concentrations, whereas no difference was found in the plasma PAF-AH mass and activity as well as in the HDL-PAF-AH activity between the 2 studied subgroups. The same phenomenon was observed for serum PON1 activities. In a multivariate analysis, only the age was significantly correlated with IMT values (p < 0.05). Neither the total plasma PAF-AH mass and activity nor the HDL-PAF-AH activity are associated with early carotid atherosclerosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000230801100013-
heal.identifier.secondaryhttp://ang.sagepub.com/content/56/4/451.full.pdf-
heal.journalNameAngiologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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