Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma
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Authors
Danielides, S.
Mavragani, C. P.
Katsakoulas, I.
Zintzaras, E.
Drosos, A. A.
Vlachoyiannopoulos, P. G.
Moutsopoulos, H. M.
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peer-reviewed
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Scandinavian Journal of Rheumatology
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OBJECTIVES: Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS: A total of 138 patients with SSc [46 with diffuse (dSSc) and 92 with limited scleroderma (lSSc)] and 100 healthy controls (HC) were tested for the presence of ATA [anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies] using a commercial enzyme-linked immunosorbent assay (ELISA). Clinical and serological data were recorded. RESULTS: An increased prevalence of anti-TPO but not anti-Tg antibodies was detected in patients with SSc compared to HC (27.5% vs. 14%, p = 0.016). Of note, a statistically significant increase of anti-TPO was detected only in patients with lSSc compared to HC (32.6% vs. 14%, p = 0.003). No correlations with other clinical features were detected. CONCLUSIONS: An increased prevalence of anti-TPO antibodies was identified in patients with lSSc. We propose that ATA testing should be offered to this subgroup of patients.
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Keywords
Adult, Aged, Antibodies, Anti-Idiotypic/*blood, Autoantibodies/blood, Case-Control Studies, Cohort Studies, Female, Humans, Iodide Peroxidase/immunology, Male, Middle Aged, Phenotype, Scleroderma, Diffuse/blood/*immunology, Scleroderma, Limited/blood/*immunology, Thyroid Gland/*immunology
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http://www.ncbi.nlm.nih.gov/pubmed/21417550
http://informahealthcare.com/doi/abs/10.3109/03009742.2010.549837
http://informahealthcare.com/doi/abs/10.3109/03009742.2010.549837
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής