Fibrinolytic defects and recurrent miscarriage: a systematic review and meta-analysis

Απλή σελίδα τεκμηρίου
dc.contributor.authorSotiriadis, A.en
dc.contributor.authorMakrigiannakis, A.en
dc.contributor.authorStefos, T.en
dc.contributor.authorParaskevaidis, E.en
dc.contributor.authorKalantaridou, S. N.en
dc.date.accessioned2015-11-24T19:15:50Z
dc.date.available2015-11-24T19:15:50Z
dc.identifier.issn0029-7844-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21569
dc.rightsDefault Licence-
dc.subjectAbortion, Habitual/*physiopathologyen
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectFactor XII/*analysis/geneticsen
dc.subjectFactor XII Deficiency/epidemiology/physiopathologyen
dc.subjectFactor XIII/geneticsen
dc.subjectFemaleen
dc.subjectFibrinolysis/*physiologyen
dc.subjectGestational Ageen
dc.subjectHumansen
dc.subjectOdds Ratioen
dc.subjectPlasminogen Activator Inhibitor 1/geneticsen
dc.subjectPolymorphism, Geneticen
dc.subjectPregnancyen
dc.titleFibrinolytic defects and recurrent miscarriage: a systematic review and meta-analysisen
heal.abstractOBJECTIVE: To systematically review evidence of the association between fibrinolytic defects and recurrent miscarriage. DATA SOURCES: MEDLINE, EMBASE, and references of retrieved articles (last update September 2006) were used. METHODS OF STUDY SELECTION: Studies comparing the prevalence of fibrinolytic defects in patients with recurrent miscarriage and control women were reviewed. Of 111 potentially relevant studies, data from 14 were integrated with meta-analytic techniques and were presented as odds ratios (ORs). TABULATION, INTEGRATION, AND RESULTS: Plasminogen activator inhibitor-1 4G/5G polymorphism (OR 1.65, 95% confidence interval [CI] 0.92-2.95) and increased plasminogen activator inhibitor activity were not significantly associated with recurrent miscarriage, although the latter showed profound heterogeneity across studies. Although factor XII C46T polymorphism is not associated with recurrent miscarriage (OR 1.07, 95% CI 0.52-2.22), factor XII deficiency is significantly associated (five studies, 1,096 women; OR 18.11, 95% CI 5.52-59.39), with minimal heterogeneity across studies. Factor XIII Val34Leu and Tyr204Phe polymorphisms were not associated with recurrent miscarriage (OR 1.24, 95% CI 0.46-3.34 and OR 2.61, 95% CI 0.45-15.16, respectively). There were no eligible studies found for the rest of the factors searched (urokinase-type plasminogen activator, tissue-type plasminogen activator, kallicrein, a2-antiplasmin, a2-macroglobulin, thrombin-activated thrombolysis inhibitor, and factor XI). Only a small minority of studies ascertained miscarriage according to specific criteria, and none of the studies provided equal examination for confounders in cases and controls. CONCLUSION: Factor XII deficiency is associated with recurrent miscarriage. Data on the other factors either fail to show association or are quite limited.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/01.AOG.0000260873.94196.d6-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17470597-
heal.journalNameObstet Gynecolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ