Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes

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dc.contributor.authorBaxevanis, C. N.en
dc.contributor.authorFrillingos, S.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorReclos, G. J.en
dc.contributor.authorArsenis, P.en
dc.contributor.authorKatsiyiannis, A.en
dc.contributor.authorAnastasopoulos, E.en
dc.contributor.authorTsolas, O.en
dc.contributor.authorPapamichail, M.en
dc.date.accessioned2015-11-24T19:19:11Z
dc.date.available2015-11-24T19:19:11Z
dc.identifier.issn0892-3973-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21940
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectHumansen
dc.subjectInterleukin-2/biosynthesisen
dc.subjectIsoantigens/administration & dosageen
dc.subjectPhytohemagglutinins/pharmacologyen
dc.subjectProtein Precursors/*pharmacologyen
dc.subjectReceptors, Interleukin-2/biosynthesis/drug effectsen
dc.subjectT-Lymphocytes/*drug effects/immunologyen
dc.subjectThymosin/*analogs & derivatives/pharmacologyen
dc.titleEnhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytesen
heal.abstractThe in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.3109/08923979009019679-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2092041-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.3109/08923979009019679-
heal.journalNameImmunopharmacol Immunotoxicolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1990-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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