Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis

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dc.contributor.authorFountoulakis, S.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorKolaitis, N.en
dc.contributor.authorFrillingos, S.en
dc.contributor.authorPhilippou, G.en
dc.contributor.authorTsatsoulis, A.en
dc.date.accessioned2015-11-24T19:24:28Z
dc.date.available2015-11-24T19:24:28Z
dc.identifier.issn1479-683X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22482
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntigens, CD95/blood/*metabolismen
dc.subjectCD4-Positive T-Lymphocytes/metabolismen
dc.subjectCD8-Positive T-Lymphocytes/metabolismen
dc.subjectChilden
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFas Ligand Protein/blood/*metabolismen
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectGraves Disease/blood/*metabolism/pathologyen
dc.subjectHashimoto Disease/blood/*metabolism/pathologyen
dc.subjectHumansen
dc.subjectLymphocytes/*metabolismen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.titleDifferential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditisen
heal.abstractOBJECTIVE: To examine whether the Fas system apoptotic molecules are differentially expressed in Graves' disease (GD) and Hashimoto's thyroiditis (HT), the two opposite phenotypes of autoimmune thyroid disease (AITD). DESIGN: The expression of Fas and Fas ligand (FasL) on peripheral CD4 and CD8 lymphocytes, and non-lymphoid immune cells as well as their soluble forms in serum from untreated patients with GD and HT were evaluated. METHODS: Flow cytometry was performed for the study of peripheral immune cells from 70 newly diagnosed patients with AITD (55 with HT and 15 with GD) and 20 controls. ELISA was used for the measurement of soluble Fas (sFas) in serum samples from a subgroup of 35 AITD patients. RESULTS: An increase in the proportion of CD4 and CD8 cells expressing Fas was found in both GD and HT, albeit with some differences, when compared with controls. Importantly, in GD patients, the intensity of Fas expression on CD4 and CD8 lymphocytes was reduced and sFas levels in serum were simultaneously increased when compared with HT patients and controls. CONCLUSIONS: The Fas system apoptotic molecules appear to be differentially expressed on peripheral lymphocytes in the two opposite phenotypes of AITD.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1530/EJE-08-0092-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18505906-
heal.identifier.secondaryhttp://www.eje-online.org/content/158/6/853.full.pdf-
heal.journalNameEuropean Journal of Endocrinologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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