Structural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactions

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dc.contributor.authorLazarou, K.en
dc.contributor.authorBednarz, B.en
dc.contributor.authorKubicki, M.en
dc.contributor.authorVerginadis, I. I.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorHadjikakou, S. K.en
dc.date.accessioned2015-11-24T16:48:10Z
dc.date.available2015-11-24T16:48:10Z
dc.identifier.issn0020-1693-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9291
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectcopper(i) complexesen
dc.subjecttriphenylphosphineen
dc.subjectcrystal structuresen
dc.subjectphotolysisen
dc.subjectbiological studiesen
dc.subjectcytotoxic activityen
dc.subjectcoinage metal-clustersen
dc.subjectd-orbital aromaticityen
dc.subjectcrystal-structureen
dc.subjectheterocyclic thionesen
dc.subjectmolecular structureen
dc.subjectliganden
dc.subjecttriphenylphosphineen
dc.subjecthydrocarbonsen
dc.subjectmononuclearen
dc.subjectphosphineen
dc.titleStructural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactionsen
heal.abstractDirect reaction of copper(I) chloride with triphenylphosphine (tpp) in molar ratio 2: 3 and 1: 3, results in the formation of the [(tpp)Cu(mu(2)-Cl)(2)Cu(tpp)(2)] (1) and {[CuCl(tpp)(3)]center dot(CH(3)CN)} (2) complexes. The complexes have been characterized by melting point, FT-IR, UV-Vis spectroscopic data and X-ray crystallography. Complex 1 is di-nuclear. Two mu(2)-Cl atoms bridge two copper(I) ions with tetrahedral and trigonal geometry respectively. The short copper-copper bond distance of 2.9039(6) angstrom in case of 1 indicates d(10)-d(10) interaction between metal centers. Thus, our studies were extended here in the determination of the quasi-aromaticity, which results in strong Cu-Cu interactions, using the computational method of nucleus-independent chemical shifts (NICS). The NICS calculated at the inner region of the Cu(2)Cl(2)P(3) core in complex 1 is shielded up to -6.05 ppm. Complex 2 is mono-nuclear where three phosphorus and one chloride atoms form a tetrahedron around the copper(I) ion. Photolysis of both complexes 1 and 2, results in the formation of triphenylphosphine oxide. The complexes 1 and 2, were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7). The type of LMS cell death caused by the complexes was also evaluated by use of a flow cytometry assay. The results show that at concentration of 5 mu M of complexes 1 and 2, 34.1% (1) and 19.6 (2)% of LMS cells undergo programmed cell death (apoptosis), while at 10 mu M, 80.4% (1) and 65.2% (2) of LMS cells undergo apoptosis. The light sensitivity of the complex is discussed in relation with the biological activity. (C) 2009 Elsevier B. V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.ica.2009.11.037-
heal.identifier.secondary<Go to ISI>://000274414700018-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0020169309006859/1-s2.0-S0020169309006859-main.pdf?_tid=85e2309d8acd95b105acc47dd78d87c3&acdnat=1333030236_d690a9ffb4ec6bc848cd6be8f7fcab5a-
heal.journalNameInorganica Chimica Actaen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2010-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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