Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer

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dc.contributor.authorDimitriadis, E.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorMilatos, S.en
dc.contributor.authorFoukas, P. G.en
dc.contributor.authorGioulbasanis, I.en
dc.contributor.authorCourtis, N.en
dc.contributor.authorNielsen, F. C.en
dc.contributor.authorPandis, N.en
dc.contributor.authorDafni, U.en
dc.contributor.authorBardi, G.en
dc.contributor.authorIoannidis, P.en
dc.date.accessioned2015-11-24T16:33:48Z
dc.date.available2015-11-24T16:33:48Z
dc.identifier.issn0020-7136-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7714
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectColonic Neoplasms/*metabolismen
dc.subjectFemaleen
dc.subjectGene Expressionen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIntestinal Mucosa/metabolismen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectRNA, Messenger/metabolismen
dc.subjectRNA-Binding Proteins/*metabolismen
dc.subjectReverse Transcen
dc.titleExpression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon canceren
heal.abstractThe oncofetal CRD-BP/IMP1 RNA binding protein regulates posttranscriptionally a handful of RNA transcripts, implicated in cell adhesion and invadopodia formation and was recently identified as a target of the beta-catenin/Tcf transcription factor that is constitutively activated in colorectal carcinomas (CRCs). The expression of CRD-BP/IMP1 was studied in normal adult intestines and CRCs. In normal mucosa, CRD-BP/IMP1 immunoreactivity was observed in few scattered cells located predominantly at or near the bottom of the crypts, whereas in CRCs the protein was detectable in tumor cells of 50% of the specimens analyzed. CRD-BP/IMP1 mRNA expression was measured by qRT-PCR in 78 CRCs. Thirty-two (41%) of the specimens were negative or had negligible expression, whereas the remaining forty-six (59%) expressed a wide range of CRD-BP/IMP1 mRNA levels. CRD-BP/IMP1 mRNA expression correlated with that of the putative stem/progenitor cell marker Musashi-1 mRNA (p = 0. 035). CRD-BP/IMP1 positive tumors metastasized and/or recurred more frequently (p = 0.001) and its expression defined a group of patients with shorter survival (p = 0.014). Furthermore, in a multivariate analysis CRD-BP/IMP1 expression was found to be an independent predictor of survival (p = 0.015). For stage I & II patients, the differences in metastasis/recurrence and survival rates remained significant (p = 0.001 and 0.033, respectively). These findings indicate that CRD-BP/IMP1 positive tumors exhibit early disease dissemination and unfavorable prognosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/ijc.22716-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17415713-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/ijc.22716/asset/22716_ftp.pdf?v=1&t=h2a39dtf&s=4e5cfbc0e464f8835c0d1e17d5c0ada5d1ebfebd-
heal.journalNameInt J Canceren
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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