Novel SYT-SSX fusion transcript variants in synovial sarcoma

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dc.contributor.authorDimitriadis, E.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorKyriazoglou, A.en
dc.contributor.authorTakou, A.en
dc.contributor.authorFrangia, K.en
dc.contributor.authorPandis, N.en
dc.contributor.authorTrangas, T.en
dc.date.accessioned2015-11-24T16:34:09Z
dc.date.available2015-11-24T16:34:09Z
dc.identifier.issn1873-4456-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7766
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAmino Acid Sequenceen
dc.subjectBase Sequenceen
dc.subjectHead and Neck Neoplasms/*genetics/metabolism/pathologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMolecular Sequence Dataen
dc.subjectNeoplasm Proteins/geneticsen
dc.subjectOncogene Proteins, Fusion/*geneticsen
dc.subjectRNA, Messenger/geneticsen
dc.subjectRepressor Proteins/genetien
dc.titleNovel SYT-SSX fusion transcript variants in synovial sarcomaen
heal.abstractSynovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation detected in >95% of cases. Through this translocation, one of the SYT genes, SYT4 on chromosome 18, is fused to one of the SSX genes on chromosome X. SYT4-SSX1 is the most common fusion subtype, present in approximately two thirds of the cases, followed by SYT4-SSX2 and, very rarely, SYT4-SSX4. Variant fusion transcripts occur less often, and most of the reported cases are the result of small insertions. Described here is a novel fusion variant containing a small deletion resulting in an alternative reading frame of the SSX part of the fusion gene. This fusion transcript may provide further insight into the oncogenic function of the SSX partner of the fusion gene.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.cancergencyto.2009.06.012-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19837269-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0165460809003318/1-s2.0-S0165460809003318-main.pdf?_tid=25849bcb1ef9a8bd30e0408c55a01a1f&acdnat=1337154688_a203313d077617ffcd309b04cd60a744-
heal.journalNameCancer Genet Cytogeneten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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