Tissue-engineered vascularized bone grafts: basic science and clinical relevance to trauma and reconstructive microsurgery
Φόρτωση...
Ημερομηνία
Συγγραφείς
Johnson, E. O.
Troupis, T.
Soucacos, P. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Microsurgery
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Bone grafts are an important part of orthopaedic surgeon's armamentarium. Despite well-established bone-grafting techniques, large bone defects still represent a challenge. Efforts have therefore been made to develop osteoconductive, osteoinductive, and osteogenic bone-replacement systems. The long-term clinical goal in bone tissue engineering is to reconstruct bony tissue in an anatomically functional three-dimensional morphology. Current bone tissue engineering strategies take into account that bone is known for its ability to regenerate following injury, and for its intrinsic capability to re-establish a complex hierarchical structure during regeneration. Although the tissue engineering of bone for the reconstruction of small to moderate sized bone defects technically feasible, the reconstruction of large defects remains a daunting challenge. The essential steps towards optimized clinical application of tissue-engineered bone are dependent upon recent advances in the area of neovascularization of the engineered construct. Despite these recent advances, however, a gap from bench to bedside remains; this may ultimately be bridged by a closer collaboration between basic scientists and reconstructive surgeons. The aim of this review is to introduce the basic principles of tissue engineering of bone, outline the relevant bone physiology, and discuss the recent concepts for the induction of vascularization in engineered bone tissue.
Περιγραφή
Λέξεις-κλειδιά
*Blood Vessel Prosthesis, Bone Regeneration/physiology, Bone Substitutes, Bone Transplantation/instrumentation/*methods, Bone and Bones/blood supply/cytology/physiology, Humans, Microsurgery/instrumentation/*methods, Neovascularization, Physiologic/physiology, Reconstructive Surgical Procedures/instrumentation/*methods, Surgical Flaps, Tissue Engineering/*methods, Tissue Scaffolds, Wounds and Injuries/surgery
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21360585
http://onlinelibrary.wiley.com/store/10.1002/micr.20821/asset/20821_ftp.pdf?v=1&t=h0updxqp&s=de2b18beb45b33542df9043c2a55343aaa089421
http://onlinelibrary.wiley.com/store/10.1002/micr.20821/asset/20821_ftp.pdf?v=1&t=h0updxqp&s=de2b18beb45b33542df9043c2a55343aaa089421
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής