Photon activation therapy and brachytherapy
| dc.contributor.author | Laster, B. H. | en |
| dc.contributor.author | Dixon, D. W. | en |
| dc.contributor.author | Novick, S. | en |
| dc.contributor.author | Feldman, J. P. | en |
| dc.contributor.author | Seror, V. | en |
| dc.contributor.author | Goldbart, Z. I. | en |
| dc.contributor.author | Kalef-Ezra, J. A. | en |
| dc.date.accessioned | 2015-11-24T18:58:36Z | |
| dc.date.available | 2015-11-24T18:58:36Z | |
| dc.identifier.issn | 1538-4721 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19295 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Brachytherapy/*methods | en |
| dc.subject | DNA, Neoplasm/metabolism | en |
| dc.subject | Female | en |
| dc.subject | Intercalating Agents/therapeutic use | en |
| dc.subject | Mammary Neoplasms, Experimental/*radiotherapy | en |
| dc.subject | Metalloporphyrins/therapeutic use | en |
| dc.subject | Mice | en |
| dc.subject | Mice, Inbred BALB C | en |
| dc.subject | Organoplatinum Compounds/therapeutic use | en |
| dc.subject | Palladium | en |
| dc.subject | *Photons | en |
| dc.subject | Radioisotopes | en |
| dc.title | Photon activation therapy and brachytherapy | en |
| heal.abstract | PURPOSE: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells. METHODS AND MATERIALS: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor. RESULTS: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only. CONCLUSIONS: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.brachy.2008.12.008 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19428312 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S1538472109001962/1-s2.0-S1538472109001962-main.pdf?_tid=a954e18460f1a70ed79d1ac81d2dcadb&acdnat=1333089084_11a81fd58e19ea3511ed6948ebc64a4d | - |
| heal.journalName | Brachytherapy | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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