Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats
Φόρτωση...
Ημερομηνία
Συγγραφείς
Konstandi, M.
Johnson, E.
Lang, M. A.
Malamas, M.
Marselos, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pharmacol Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The effect of restraint stress on central neurotransmission was evaluated in mice and rats. Noradrenaline (NA), dopamine (DA) and serotonin (5-HT) levels and their primary metabolites were measured in discrete brain regions following exposure to stress. Mice and rats demonstrated a similar response to stress in some brain regions. Both species responded to stress with lower NA and 5-HT in the locus coeruleus compared to non-stressed controls. Dopaminergic activity, assessed by DA turnover, was elevated in the hypothalamus. While DA turnover was suppressed in the amygdala, 5-HT turnover was similarly elevated in both species. In most cases, however, there were differences in biogenic neurotransmission between mice and rats in response to stress. In particular, NA levels were suppressed by stress in the dorsal cortex of mice, but in the rats NA levels were decreased in the hypothalamus. While stress produced lower DA levels in the hypothalamus, DA levels demonstrated a marked increase in the amygdala of mice. Stress was also associated with a decrease in DA levels in the rat striatum and with an increase of DA turnover in the locus coeruleus of mice. On the other hand, 5-HT was suppressed in the mouse striatum and in the rat hypothalamus and amygdala, while 5-HT turnover was markedly decreased in the hippocampus and dorsal cortex of rats alone. In conclusion, the changes in the central neurotransmission which are evoked by stress appear to be species-specific in most cases, a fact which may trigger discrete alterations in homeostatic mechanisms.
Περιγραφή
Λέξεις-κλειδιά
Animals, Biogenic Amines/*metabolism, Brain/*metabolism, Corticosterone/blood, Dopamine/metabolism, Male, Mice, Mice, Inbred DBA, Norepinephrine/metabolism, Rats, Rats, Wistar, Serotonin/metabolism, Stress, Psychological/blood/*metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10675287
http://ac.els-cdn.com/S1043661899905972/1-s2.0-S1043661899905972-main.pdf?_tid=499f51d1aa87cab8728ee8fde3b2aa24&acdnat=1332759639_c62d24ffd3847554dd09d0f09b78af0e
http://ac.els-cdn.com/S1043661899905972/1-s2.0-S1043661899905972-main.pdf?_tid=499f51d1aa87cab8728ee8fde3b2aa24&acdnat=1332759639_c62d24ffd3847554dd09d0f09b78af0e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής