Acute changes in N-terminal pro-brain natriuretic peptide induced by dobutamine stress echocardiography

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dc.contributor.authorKarabinos, I.en
dc.contributor.authorKarvouni, E.en
dc.contributor.authorChiotinis, N.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorSimeonidis, P.en
dc.contributor.authorTsolas, O.en
dc.contributor.authorKatritsis, D.en
dc.date.accessioned2015-11-24T19:38:08Z
dc.date.available2015-11-24T19:38:08Z
dc.identifier.issn1525-2167-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24113
dc.rightsDefault Licence-
dc.subjectAcute Diseaseen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBiological Markersen
dc.subjectCoronary Artery Disease/diagnosis/*ultrasonographyen
dc.subject*Echocardiography, Stressen
dc.subjectExercise Testen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Ischemia/etiology/*physiopathologyen
dc.subjectNatriuretic Peptide, Brain/analysis/*physiologyen
dc.subjectPeptide Fragments/analysis/*physiologyen
dc.subjectProspective Studiesen
dc.subjectStroke Volumeen
dc.subjectVentricular Function, Leften
dc.titleAcute changes in N-terminal pro-brain natriuretic peptide induced by dobutamine stress echocardiographyen
heal.abstractAIMS: Aim of the study was to determine the effect of dobutamine stress echocardiography (DSE)-induced ischemia on circulating levels of N-terminal fragment of B-type natriuretic peptide (NT-pro-BNP). METHODS AND RESULTS: One hundred and twenty-eight patients underwent DSE for the evaluation of known or suspected coronary artery disease. NT-pro-BNP levels were measured before and 1h after completion of DSE. NT-pro-BNP levels were similar before and after DSE regardless of whether patients had (123+/-101.8 vs. 124.2+/-108.3, p=NS) or did not have inducible ischemia (96.5+/-70.5 vs. 100.5+/-71.1, p=NS). Patients with inducible myocardial ischemia had no different NT-pro-BNP levels compared to patients without inducible ischemia both before (123+/-101.8 vs. 96.5+/-70pg/ml, p=0.37) and after DSE (124.2+/-108.3 vs. 100.5+/-71.1pg/ml, p=0.55). Patients with severe inducible ischemia had significantly higher NT-pro-BNP levels compared to patients with mild or moderate inducible ischemia and patients without inducible ischemia, both before (208.5+/-125.5 vs. 96+/-78.9 vs. 96.5+/-70pg/ml, p=0.017 and p=0.025, respectively) and after DSE (212.5+/-138.1 vs. 94.8+/-81.1 vs. 100.5+/-71.1pg/ml, p=0.015 and p=0.023, respectively). NT-pro-BNP levels before DSE could be independently predicted by age (p<0.0001), presence of diabetes mellitus (p=0.002), and ejection fraction (p=0.005), but not DSE inducible ischemia. CONCLUSION: NT-pro-BNP is not affected by DSE-induced ischemia and cannot be used in clinical practice to improve diagnostic accuracy of DSE.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.euje.2006.06.003-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16849043-
heal.identifier.secondaryhttp://ehjcimaging.oxfordjournals.org/content/8/4/265.full.pdf-
heal.journalNameEur J Echocardiogren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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