The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype

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dc.contributor.authorXita, N.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorLazaros, L.en
dc.contributor.authorPsofaki, V.en
dc.contributor.authorKolios, G.en
dc.contributor.authorTsatsoulis, A.en
dc.date.accessioned2015-11-24T19:23:52Z
dc.date.available2015-11-24T19:23:52Z
dc.identifier.issn1479-683X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22375
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAnalysis of Varianceen
dc.subjectAndrogens/blooden
dc.subjectAromatase/*genetics/metabolismen
dc.subjectBase Sequenceen
dc.subjectBody Mass Indexen
dc.subjectEstradiol/blooden
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInsulin Resistanceen
dc.subjectPhenotypeen
dc.subjectPolycystic Ovary Syndrome/blood/genetics/*pathologyen
dc.subjectPolymerase Chain Reactionen
dc.subject*Polymorphism, Geneticen
dc.subjectSex Hormone-Binding Globulin/*genetics/metabolismen
dc.subjectTestosterone/blooden
dc.titleThe synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotypeen
heal.abstractOBJECTIVE: Experimental evidence suggests that fetal exposure to androgen excess may program the development of polycystic ovary syndrome (PCOS) in utero. The aim of this study was to examine whether the sex hormone binding globulin (SHBG)(TAAAA)n and the cytochrome P450, family 19 (CYP19)(TTTA)n polymorphisms, known to influence sex hormone-binding globulin (SHBG) levels and aromatase activity respectively, play a synergistic role in the development of PCOS. DESIGN AND METHODS: We studied 180 women with PCOS and 160 healthy women of reproductive age. The body mass index (BMI) was recorded and the hormonal profile determined from the third to fifth day of menstrual cycle. DNA was extracted from blood leucocytes and the SHBG(TAAAA)n and CYP19(TTTA)n polymorphisms were genotyped. RESULTS: Genotype analysis revealed 6 SHBG(TAAAA)n alleles with 6-11 repeats and 6 CYP19(TTTA)n alleles with 7-12 repeats. Women were subdivided into four groups: those with short SHBG (< or = 8 TAAAA repeats) and CYP19 alleles (< or = 9 TTTA repeats), those with short SHBG-long CYP19 alleles, those with long SHBG-short CYP19 alleles, and those with long SHBG and CYP19 alleles. Women with PCOS tended to have at greater frequency, long SHBG-short CYP19 alleles compared with controls (57.3 vs 42.4%, P=0.07). Importantly, PCOS women with long SHBG-short CYP19 alleles had the lowest SHBG levels (P=0.02) and the highest total testosterone (P=0.008), free androgen index (P=0.002), DHEAS (P=0.02), and testosterone/estradiol ratio (P=0.03), compared with those with other genotypes. This association was independent of age, BMI, and insulin resistance indexes. CONCLUSION: We speculate that the SHBG and CYP19 genes may have a synergistic role in the developmental programming of PCOS, by affecting androgen bioavailability and aromatization respectively.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1530/EJE-07-0905-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18505907-
heal.identifier.secondaryhttp://www.eje-online.org/content/158/6/861.full.pdf-
heal.journalNameEuropean Journal of Endocrinologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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