A novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomas

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dc.contributor.authorKin, Y.en
dc.contributor.authorChintala, S. K.en
dc.contributor.authorGo, Y.en
dc.contributor.authorSawaya, R.en
dc.contributor.authorMohanam, S.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorRao, J. S.en
dc.date.accessioned2015-11-24T19:40:04Z
dc.date.available2015-11-24T19:40:04Z
dc.identifier.issn1019-6439-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24295
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subject*Apoptosisen
dc.subjectBrain Neoplasms/*pathology/*physiopathology/prevention & controlen
dc.subjectDNA, Antisense/pharmacologyen
dc.subjectFemaleen
dc.subjectGlioma/*pathology/*physiopathology/prevention & controlen
dc.subjectHumansen
dc.subjectIn Situ Nick-End Labelingen
dc.subjectMiceen
dc.subjectMice, Nudeen
dc.subjectNeoplasm Invasiveness/prevention & controlen
dc.subjectPlasminogen Activators/physiologyen
dc.subjectReceptors, Cell Surface/genetics/*physiologyen
dc.subjectReceptors, Urokinase Plasminogen Activatoren
dc.subjectTransfectionen
dc.subjectTransplantation, Heterologousen
dc.subjectTumor Cells, Cultureden
dc.titleA novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomasen
heal.abstractGlioblastomas express more urokinase-type plasminogen activator receptor (uPAR) than do low-grade gliomas and normal brain tissue. We previously showed that downregulation of uPAR through the transfection of SNB19 cells with an antisense cDNA construct corresponding to 300 bp of the 5' end of the human uPAR gene inhibited tumor cell invasion in vitro and tumor formation in vivo. Here we sought to determine whether uPAR is necessary for cell survival and whether the inhibition of tumor formation in nude mice is due to apoptosis of intracerebrally injected SNB19 cells. Apoptosis measured by DNA fragmentation were higher in the brains of animals injected with the antisense stable transfectants than in those injected with the parental cells. Moreover, the increase in apoptotic cell death in vitro was associated with increased expression of apoptotic protein BAX in antisense clones compared to controls. To our knowledge, this is the first report of uPAR playing a novel role in cell survival in human gliomas.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10853019-
heal.journalNameInt J Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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