Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission
Loading...
Date
Authors
Dalla, C.
Antoniou, K.
Kokras, N.
Drossopoulou, G.
Papathanasiou, G.
Bekris, S.
Daskas, S.
Papadopoulou-Daifoti, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Physiol Behav
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Sex differences in behavioral and neurobiological responses to stress are considered to modulate the prevalence of some psychiatric disorders, including major depression. In the present study, we compared dopaminergic neurotransmission and behavior in response to two different stress paradigms, the Forced Swim Test (FST) and the Chronic Mild Stress (CMS). Male and female rats were subjected to one session of swim stress for two consecutive days (FST) or to a variety of mild stressors alternating for six weeks (CMS). Subsequently, the tissue levels of dopamine (DA) and its metabolites (HVA and DOPAC) in the hippocampus, the hypothalamus, the prefrontal cortex and the striatum were measured using high-performance liquid chromatography (HPLC). The ratios HVA/DA and DOPAC/DA were also calculated as indices of the dopaminergic activity. Results from the FST determined that males exhibited lower immobility, higher climbing duration and increased dopaminergic activity in the prefrontal cortex and the hippocampus compared to females. CMS induced alterations in sucrose intake in both sexes, while it only decreased dopaminergic activity in the prefrontal cortex of females. These findings show that FST and CMS have different effects on the dopaminergic activity of discrete brain regions depending on the sex of the animal. These data support the growing evidence that females display a differential response and adaptation to stress than males.
Description
Keywords
Analysis of Variance, Animals, Behavior, Animal, Brain/metabolism/pathology, Brain Chemistry/*physiology, Dopamine/*metabolism, Female, Food Preferences/physiology, Male, Rats, Rats, Wistar, *Sex Characteristics, Stress, Psychological/etiology/*metabolism/pathology, Swimming, Time Factors
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/18031771
http://ac.els-cdn.com/S0031938407004143/1-s2.0-S0031938407004143-main.pdf?_tid=b889a7b923036a05be8b28bb6349216d&acdnat=1332924907_65dcb87fad36b83b8397bcfb0ebcec17
http://ac.els-cdn.com/S0031938407004143/1-s2.0-S0031938407004143-main.pdf?_tid=b889a7b923036a05be8b28bb6349216d&acdnat=1332924907_65dcb87fad36b83b8397bcfb0ebcec17
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής