Bronchoalveolar lavage alterations during prolonged ventilation of patients without acute lung injury
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tsangaris, I.
Lekka, M. E.
Kitsiouli, E.
Constantopoulos, S.
Nakos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
European Respiratory Society: ERJ
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
European Respiratory Journal
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Mechanical ventilation deteriorates previously injured lung, but little is known about its effect on healthy human lung. This work was designed to assess the effect of prolonged mechanical ventilation on bronchoalveolar lavage (BAL) fluid composition of patients without acute lung injury. Twenty-two ventilated patients (tidal volume 8-10 mL(.)kg(-1), positive end-expiratory pressure 3-5 emH(2)O) without lung injury,. who did not develop any complication from the respiratory system during the 2-week study period, were studied. They were subjected to three consecutive BALs, the first during 36 h from intubation, the second at the end of the first week of mechanical ventilation and the third at the end of the second week of mechanical ventilation. Total BAL protein increased during mechanical ventilation (148 62, 381 288, 353+/-215 mug(.)mL(-1) BAL for the first, second and third BAL, respectively). In contrast, BAL phospholipids decreased (2.7+/-1.1, 1.4+/-0.6, 1.2+/-0.7 mug(.)mL(-1) BAL, respectively). Large surfactant aggregates were reduced and inflammatory markers, such as platelet activating factor (PAF), PAF-acetylhydrolase and neutrophils, significantly increased after 1 week, but partially remitted after 2 weeks of mechanical ventilation. In summary, this study demonstrates that prolonged mechanical ventilation even of patients without acute. lung injury is associated with the presence of inflammatory markers and surfactant alterations.
Περιγραφή
Λέξεις-κλειδιά
bronchoalveolar lavage, mechanical ventilation, platelet activating factor, surfactant, ventilator-associated lung injury, respiratory-distress syndrome, surfactant aggregate conversion, mechanical ventilation, pulmonary-surfactant, alveolar surfactant, dogs lungs, in-vitro, cytokines, clearance, proteins
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000181578200021
http://erj.ersjournals.com/content/21/3/495.full.pdf
http://erj.ersjournals.com/content/21/3/495.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας