Protein Z Plasma Levels are Not Elevated in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy
| dc.contributor.author | Asproudis, I. | en |
| dc.contributor.author | Felekis, T. L. | en |
| dc.contributor.author | Gorezis, S. | en |
| dc.contributor.author | Dova, L. | en |
| dc.contributor.author | Dokou, E. | en |
| dc.contributor.author | Vartholomatos, G. | en |
| dc.contributor.author | Aspiotis, M. | en |
| dc.contributor.author | Kolaitis, N. I. | en |
| dc.date.accessioned | 2015-11-24T18:55:54Z | |
| dc.date.available | 2015-11-24T18:55:54Z | |
| dc.identifier.issn | 1874-3641 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18951 | |
| dc.rights | Default Licence | - |
| dc.title | Protein Z Plasma Levels are Not Elevated in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy | en |
| heal.abstract | BACKGROUND: Protein Z is a glycoprotein that acts as a co-factor for the inhibition of activated coagulation factor X. Protein Z circulating in abnormal levels has been associated with increased risk for acute ischemic events. Non-arteritic Anterior Ischemic Optic Neuropathy (N-AION) is caused by acute ischemic infarction of the optic nerve head, supplied by the posterior ciliary arteries. OBJECTIVES: The aim was to investigate whether there is an association between N-AION and plasma protein Z levels. PATIENTS AND METHODS: Twenty-six cases of confirmed N-AION and fifty-two controls were included in the study group. Protein Z was estimated in thawed citrate plasma on both N-AION cases and controls by an enzyme immunoassay. The imprecision of the estimation was satisfactory (CV = 4, 6%). RESULTS: The controls' protein Z values distributed within a range 340 to 4200 ng/ml (median = 1420, mean = 1673, SD = 1040 ng/ml). Patients' protein Z values distributed within a range 420 to 3600 ng/ml (median = 1030, mean = 1520, SD = 939 ng/ml). There was no statistical difference between the two distributions (Independent t-test, p=0.529). CONCLUSION: In our study, protein Z levels are not implicated in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (N-AION). | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.2174/1874364100903010015 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19554219 | - |
| heal.journalName | Open Ophthalmol J | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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