Cell proliferation in human tumours growing in nude mice: renal cell carcinomas, larynx and hypopharynx carcinomas

Απλή σελίδα τεκμηρίου
dc.contributor.authorMaurer-Schultze, B.en
dc.contributor.authorBassukas, I. D.en
dc.contributor.authorBoswald, M.en
dc.contributor.authorHarasim, M.en
dc.date.accessioned2015-11-24T19:31:18Z
dc.date.available2015-11-24T19:31:18Z
dc.identifier.issn0171-5216-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23244
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCarbon Radioisotopesen
dc.subjectCarcinoma, Renal Cell/*pathologyen
dc.subjectCell Count/drug effectsen
dc.subjectCell Cycle/physiologyen
dc.subjectDNA, Neoplasm/analysisen
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectHypopharyngeal Neoplasms/*pathologyen
dc.subjectKidney Neoplasms/*pathologyen
dc.subjectLaryngeal Neoplasms/*pathologyen
dc.subjectMaleen
dc.subjectMetaphase/physiologyen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subjectNecrosisen
dc.subjectNeoplasm Transplantationen
dc.subjectS Phase/physiologyen
dc.subjectTransplantation, Heterologousen
dc.subjectTritiumen
dc.subjectVincristine/pharmacologyen
dc.titleCell proliferation in human tumours growing in nude mice: renal cell carcinomas, larynx and hypopharynx carcinomasen
heal.abstractCell proliferation of 51 human renal cell carcinomas and 9 larynx and hypopharynx carcinomas has been studied in vitro and using xenotransplants. The proliferative activity ([3H]thymidine labelling index) increases during the first passages in nude mice and then remains almost constant throughout subsequent passages. A comparison of cell kinetic parameters of 8 human renal cell carcinomas, 1 hypopharynx and 2 larynx carcinomas, with data of xenografts and of human tumours in situ published up to now, shows that the cell kinetic parameters of human tumour xenografts presently studied range between those of human tumours in situ and those of autochthonous or transplantable mouse tumours. S-phase durations and potential doubling times are considerably shorter in xenotransplants than in human tumours in situ, whereas the cycle time is about the same. This means that the growth fraction increases considerably after xenotransplantation. This change of human tumour cell proliferation after transplantation into nude mice should be kept in mind if one wishes to draw conclusions from the nude mouse model on conditions in human beings, particularly with respect to therapeutic regimens, which are frequently tested in the nude mouse model.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1577846-
heal.identifier.secondaryhttp://www.springerlink.com/content/nr6702q47q368376/fulltext.pdf-
heal.journalNameJ Cancer Res Clin Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ