Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis

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dc.contributor.authorTaskapan, H.en
dc.contributor.authorErsoy, F. F.en
dc.contributor.authorPassadakis, P. S.en
dc.contributor.authorTam, P.en
dc.contributor.authorMemmos, D. E.en
dc.contributor.authorKatopodis, K. P.en
dc.contributor.authorOzener, C.en
dc.contributor.authorAkcicek, F.en
dc.contributor.authorCamsari, T.en
dc.contributor.authorAtes, K.en
dc.contributor.authorAtaman, R.en
dc.contributor.authorVlachojannis, J. G.en
dc.contributor.authorDombros, N. A.en
dc.contributor.authorUtas, C.en
dc.contributor.authorAkpolat, T.en
dc.contributor.authorBozfakioglu, S.en
dc.contributor.authorWu, G.en
dc.contributor.authorKarayaylali, I.en
dc.contributor.authorArinsoy, T.en
dc.contributor.authorStathakis, C. P.en
dc.contributor.authorYavuz, M.en
dc.contributor.authorTsakiris, D. J.en
dc.contributor.authorDimitriades, A. D.en
dc.contributor.authorYilmaz, M. E.en
dc.contributor.authorGultekin, M.en
dc.contributor.authorOreopoulos, D. G.en
dc.date.accessioned2015-11-24T18:51:50Z
dc.date.available2015-11-24T18:51:50Z
dc.identifier.issn0301-0430-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18317
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCross-Sectional Studiesen
dc.subjectDiabetic Nephropathies/therapyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKidney Failure, Chronic/*complications/etiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPeritoneal Dialysis/*adverse effectsen
dc.subjectVitamin D/blooden
dc.subjectVitamin D Deficiency/*complications/epidemiology/*etiologyen
dc.titleSevere vitamin D deficiency in chronic renal failure patients on peritoneal dialysisen
heal.abstractThe aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers. METHOD: This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism. RESULTS: Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3. CONCLUSION: We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17063991-
heal.journalNameClin Nephrolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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