Subthreshold membrane-potential oscillations in immature rat CA3 hippocampal neurones.

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dc.contributor.authorPsarropoulou, C.en
dc.contributor.authorAvoli, M.en
dc.date.accessioned2015-11-24T16:35:14Z
dc.date.available2015-11-24T16:35:14Z
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7918
dc.rightsDefault Licence-
dc.titleSubthreshold membrane-potential oscillations in immature rat CA3 hippocampal neurones.en
heal.abstractSubthreshold membrane potential oscillations (MPOs) were recorded intracellularly in 31 of 43 (>70%) immature CA3 hippocampal neurones (from 3-17 days postnatally). MPOs (3-5 mV, 3-15 Hz) occurred at resting membrane potential (RMP) in 20 of 31 neurones, or following depolarization (11 of 31 neurones); with sufficient depolarization spontaneous action potentials (APs) were generated from the positive-going phase of MPOs. In all cells, MPOs were blocked by steady membrane hyperpolarization. Tetrodotoxin abolished MPOs (n = 4); Co(2+) markedly reduced them (n = 3), and tetraethylammonium, added in the presence of TTX, revealed lower frequency oscillatory activity (n = 2). We conclude that subthreshold MPOs in immature hippocampus, possibly linked to theta rhythm generation and memory acquisition, depend on voltage-dependent Na+ electrogenesis and they might be additionally controlled by Ca(2+) and K+ conductances.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.journalNameNeuroreporten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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