Zinc(II) complexes derived from pyridine-2-carbaldehyde thiosemicarbazone and (1E)-1-pyridin-2-ylethan-1-one thiosemicarbazone. Synthesis, crystal structures and antiproliferative activity of zinc(II) complexes
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kovala-Demertzi, D.
Yadav, P. N.
Wiecek, J.
Skoulika, S.
Varadinova, T.
Demertzis, M. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The complexes [ZnCl2(HFoTsc) center dot H2O], [Zn(FoTsC)(2)], [ZnCl2(HAcTsc) center dot H2O] and [Zn(AcTsc)(2)], where HFoTsc and HAcTsc is pyridine-2-carbaldehyde thiosemicarbazone and (1E)-1-pyridin-2-ylethan-1-one, thiosemicarbazone respectively, have been prepared and structurally characterized by means vibrational, and NMR (H-1 and C-13) spectroscopy. The crystal structures of the complexes [ZnCl2(HFoTsc) center dot H2O], [Zn(AcTsc)(2)] and [ZnCl2(HAcTsc) center dot H2O] have been determined by X-ray crystallography. The metal co-ordination geometry of [ZnCl2(HFoTsc) center dot H2O] and [ZnCl2(HAcTsc) center dot H2O] is described as distorted square pyramidal and the two complexes are self-assembled via pi -> pi stacking interactions and intermolecular hydrogen bonds. In these two cases molecular recognition of the hydrogen bonds leads to aggregation and a supramolecular assembly of infinite two-dimensional network. The metal co-ordination geometry of [Zn(AcTSC)21 is described as distorted octahedral configuration in a trans-N(2)-cis-N(1)-cis-S configuration. HFoTsc and HAcTsc and the zinc complexes have been evaluated for antiproliferative activity in vitro against the cells of two human cancer cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line) and a mouse fibroblast L-929 cell line. The cytotoxic activity shown by these compounds indicates that coupling of HFoTsc and HAcTsc to Zn(II) metal center result in metallic complexes with important biological properties since they display IC50 values in a mu M range similar to or better than that of the antitumor drug cis-platin and are considered as agents with potential antitumor activity candidates for further stages of screening in vitro and/or in vivo. (c) 2006 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
thiosemicarbazones, zinc complexes, crystal structures, spectroscopic studies, antiproliferative activity, palladium(ii) complexes, metal-complexes, platinum(ii), ligands, assay
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000240789000015
http://ac.els-cdn.com/S0162013406001577/1-s2.0-S0162013406001577-main.pdf?_tid=a6b7d1cdc836f98871af7337eeae35a6&acdnat=1333028850_5accfd2de9aaccf245bec0aa37dd526f
http://ac.els-cdn.com/S0162013406001577/1-s2.0-S0162013406001577-main.pdf?_tid=a6b7d1cdc836f98871af7337eeae35a6&acdnat=1333028850_5accfd2de9aaccf245bec0aa37dd526f
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας