Evaluation of the association of autoantibodies with mortality in the very elderly: a cohort study

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorKatsifis, G. E.en
dc.contributor.authorStavropoulos, E. D.en
dc.contributor.authorManoussakis, M. N.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:17:39Z
dc.date.available2015-11-24T19:17:39Z
dc.identifier.issn1462-0324-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21800
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAging/*immunologyen
dc.subjectAntibodies, Anticardiolipin/blooden
dc.subjectAntibodies, Antinuclear/blooden
dc.subjectAutoantibodies/*blooden
dc.subjectCohort Studiesen
dc.subjectDNA, Single-Stranded/immunologyen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectProportional Hazards Modelsen
dc.subjectRheumatoid Factor/blooden
dc.subjectRisk Factorsen
dc.subjectSurvival Analysisen
dc.subjectSurvival Rateen
dc.titleEvaluation of the association of autoantibodies with mortality in the very elderly: a cohort studyen
heal.abstractOBJECTIVE: To evaluate whether autoantibodies in the absence of rheumatic diseases increase the risk of mortality among very elderly subjects who are otherwise in good functional condition. METHODS: Autoantibodies were measured in 1987 in 156 elderly nursing home residents (median age 84 yr) who were followed subsequently over 14.6 yr. RESULTS: Eleven subjects had anticardiolipin antibodies, 30 had rheumatoid factor and 19 had antibodies to single-stranded DNA (ssDNA). Other autoantibodies were more rare. During follow-up, 144 subjects died. Adjusting for age as a time-dependent covariate, the hazard ratio for death was 0.71 [95% confidence interval (CI) 0.38-1.32] for anticardiolipin antibodies, 0.93 (95% CI 0.60-1.41) for rheumatoid factor, 1.08 (95% CI 0.65-1.79) for antibodies to ssDNA, and 0.99 (95% CI, 0.70-1.41) for any autoantibody. Hazard ratios were similar when adjusted also for sex and clinical conditions. CONCLUSION: Our results exclude the possibility that the autoantibodies evaluated increase substantially the risk of death among very elderly subjects in good functional condition.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12595636-
heal.journalNameRheumatology (Oxford)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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