The role of matrix metalloproteinase 9 in intervertebral disc degeneration
| dc.contributor.author | Zigouris, A. | en |
| dc.contributor.author | Alexiou, G. A. | en |
| dc.contributor.author | Batistatou, A. | en |
| dc.contributor.author | Voulgaris, S. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.date.accessioned | 2015-11-24T19:29:49Z | |
| dc.date.available | 2015-11-24T19:29:49Z | |
| dc.identifier.issn | 1532-2653 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22998 | |
| dc.rights | Default Licence | - |
| dc.title | The role of matrix metalloproteinase 9 in intervertebral disc degeneration | en |
| heal.abstract | The present study investigates the histological alterations and expression of matrix metalloproteinase 9 (MMP-9) in disc specimens of 43 patients who underwent surgery for lumbar disc herniation. The immunostaining for MMP-9 was evaluated semi-quantitatively. Histologic degeneration was scored between 0 and 12 depending on the degree of chondrocyte proliferation and presence of tears and clefts, granular changes and mucous degeneration. Herniation was graded as grade 1 (protrusion), grade 2 (extrusion) or grade 3 (sequestration) on MRI. Although there was no significant statistical difference between the histologic degeneration score and age, degenerative changes were more pronounced in higher grade of herniation (p<0.0001). MMP-9 expression was related to histologic degenerative score in all age groups (p=0.0065). MMP-9 was also related to herniation grade in patients younger than 30 years of age (p=0.0037). No significant association was found between MMP-9 expression and herniation grade in patients who were 30-60 years or over 60 years of age. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.jocn.2011.01.036 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21763143 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S096758681100227X/1-s2.0-S096758681100227X-main.pdf?_tid=b81e2019a4fbe3d0f29bf5e60ffe288d&acdnat=1333349617_d0d2caf958ed016d97e3f298d8d6be91 | - |
| heal.journalName | J Clin Neurosci | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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