Analysis of antihypertensive effects of statins
Φόρτωση...
Ημερομηνία
Συγγραφείς
Milionis, H. J.
Liberopoulos, E. N.
Elisaf, M. S.
Mikhailidis, D. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Curr Hypertens Rep
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Hypertension and hyperlipidemia, two powerful risk factors of cardiovascular disease (CVD), often coexist. Therefore, treatment should consider the beneficial properties of drugs used to treat either condition. Statins, the mainstay of lipid-lowering therapy, result in a significant clinical benefit both in primary and secondary CVD prevention. In addition to their hypolipidemic capacity, other properties may contribute to statin-induced benefits. Clinical and experimental evidence indicates that statins may modulate blood pressure (BP). The mechanisms by which statins reduce BP seem to be largely independent of their lipid effects. Although small, reductions in BP are possibly clinically relevant. Large landmark studies confirm that statins can reduce CVD risk in hypertensive patients. These findings suggest that statins could be prescribed as an adjunct in treating hypertension with dyslipidemia or even in patients with "normal" cholesterol levels. Whether the effect of statins on BP is accompanied by an additional decrease in clinical outcomes needs to be investigated in long-term, large-scale trials.
Περιγραφή
Λέξεις-κλειδιά
Animals, Antihypertensive Agents/*pharmacology, Blood Pressure/*drug effects, Endothelin-1/drug effects/metabolism, Endothelium, Vascular/drug effects/metabolism/physiopathology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology, Hyperlipidemias/drug therapy/genetics/metabolism/physiopathology, Hypertension/drug therapy/genetics/metabolism/physiopathology, Intracellular Signaling Peptides and Proteins/drug effects/metabolism, Nitric Oxide/biosynthesis, Protein-Serine-Threonine Kinases/drug effects/metabolism, Renin-Angiotensin System/drug effects, rho-Associated Kinases
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17519121
http://www.springerlink.com/content/p476108w2tj28563/fulltext.pdf
http://www.springerlink.com/content/p476108w2tj28563/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής