Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours

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dc.contributor.authorSchweigerer, L.en
dc.contributor.authorChristeleit, K.en
dc.contributor.authorFleischmann, G.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorWahala, K.en
dc.contributor.authorHase, T.en
dc.contributor.authorSchwab, M.en
dc.contributor.authorLudwig, R.en
dc.contributor.authorFotsis, T.en
dc.date.accessioned2015-11-24T19:12:22Z
dc.date.available2015-11-24T19:12:22Z
dc.identifier.issn0014-2972-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21063
dc.rightsDefault Licence-
dc.subjectCell Division/drug effectsen
dc.subjectChilden
dc.subjectGenisteinen
dc.subjectGrowth Inhibitors/chemistry/pharmacology/*urineen
dc.subjectHumansen
dc.subjectIsoflavones/chemistry/pharmacology/*urineen
dc.subjectMolecular Structureen
dc.subjectNeoplasms/*urineen
dc.subjectNeuroblastoma/drug therapyen
dc.subjectStructure-Activity Relationshipen
dc.subjectTumor Cells, Cultured/drug effectsen
dc.titleIdentification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumoursen
heal.abstractPartially purified urine of healthy human subjects contains several fractions able to inhibit the proliferation of cultured human neuroblastoma cells. One of the most active fractions was further analysed by gas chromatography-mass spectrometry and shown to contain genistein, a substance formed in the human body from precursors obtained by diet. Synthetic genistein was able to inhibit the proliferation of human neuroblastoma cells with a half-maximal effect at 5-10 mumol l-1 concentrations. Genistein displayed similar potencies in inhibiting the proliferation of cells derived from various other solid pediatric tumours. Our results suggest that genistein is a natural antineoplastic agent present in diet and that it could be useful for the therapy of paediatric tumours.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1499641-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2362.1992.tb01460.x/asset/j.1365-2362.1992.tb01460.x.pdf?v=1&t=h09auq26&s=0e21e41019faa05c4fcb9b0f819a20e083ba684e-
heal.journalNameEur J Clin Investen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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