Heterogeneous photocatalytic degradation of the pharmaceutical agent salbutamol in aqueous titanium dioxide suspensions

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dc.contributor.authorSakkas, V. A.en
dc.contributor.authorCalza, P.en
dc.contributor.authorMedana, C.en
dc.contributor.authorVillioti, A. E.en
dc.contributor.authorBaiocchi, C.en
dc.contributor.authorPelizzetti, E.en
dc.contributor.authorAlbanis, T.en
dc.date.accessioned2015-11-24T16:38:47Z
dc.date.available2015-11-24T16:38:47Z
dc.identifier.issn0926-3373-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8083
dc.rightsDefault Licence-
dc.subjectphotocatalysisen
dc.subjecttio2en
dc.subjectexperimental designen
dc.subjectmineralizationen
dc.subjecttoxicityen
dc.subjectsalbutamolen
dc.subjectaquatic environmenten
dc.subjectsolar lighten
dc.subjectno3 ionsen
dc.subjectazo-dyeen
dc.subjectwateren
dc.subjecttio2en
dc.subjectoxidationen
dc.subjectriversen
dc.subjectdrugsen
dc.subjectphotodegradationen
dc.titleHeterogeneous photocatalytic degradation of the pharmaceutical agent salbutamol in aqueous titanium dioxide suspensionsen
heal.abstractThe present paper deals with the photocatalytic transformation of salbutamol [2-(tert-butylamino)-1-(4-hydroxyl-3-hydroxymethylphenyl)ethanol] under simulated solar irradiation using titanium dioxide as a photocatalyst. The investigation has involved a kinetic study of the drug decomposition, the identification of intermediate compounds, the assessment of mineralization, as well as toxicity evaluation. The variation of TiO2 concentration and pH on the reaction rate was investigated. The use of the response surface methodology allowed to fit the optimal values of the parameters leading to the degradation of the micro-pollutant. High resolution mass spectrometry was employed in assessing the temporal course of the photocatalyzed process. According to our findings, a tentative degradation pathway is proposed for the photocatalytic degradation of salbutamol based on the formation of both oxidative and reductive compounds. 2-(Methylamino)-1-(4-hydroxyl-3-methylphenyl)ethanol, 2-(tertbutylamino)-1-(4-hydroxylphenyl)ethanol, 2-(tert-butylamino)-1-(3,4-dihydroxyphenyl)ethanol, 2-(tert-butylamino)-1-(4-hydroxyl-3-methylphenyi)ethanol, and 2-(tert-butylamino)-1-(3,4-dihydroxyphenyl)ethanone are initially formed, which are then transformed into 2-(tert-butylamino)-acetic acid and hydroquinone. All these intermediates are easily degraded themselves and until 2 h of irradiation 2-(tert-butylamino)-acetic acid is the only compound recognized to endure. Photomineralization of the substrate was rather a quick process; within 2 h of irradiation nitrogen is completely mineralized, where the amino moiety is mainly transformed into NH4+ and in a lesser extent into NO3- ions (ratio 2:1). Carbon complete mineralization is achieved within 3 h of irradiation. Finally, Microtox bioassay (Vibrio fischeri) was employed in evaluating the ecotoxicity of solutions treated by photocatalysis. (C) 2007 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.apcatb.2007.07.017-
heal.identifier.secondary<Go to ISI>://000251666400016-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0926337307002093/1-s2.0-S0926337307002093-main.pdf?_tid=bdc557bb143c0e20c50a2cd6718ce1f3&acdnat=1333023355_c25284d1add078aee2f871c766ee9001-
heal.journalNameApplied Catalysis B-Environmentalen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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