Plasma and urinary oestrogens in breast cancer patients on treatment with 4-hydroxyandrostenedione
| dc.contributor.author | Johannessen, D. C. | en |
| dc.contributor.author | Adlercreutz, H. | en |
| dc.contributor.author | Fotsis, T. | en |
| dc.contributor.author | Lonning, P. E. | en |
| dc.date.accessioned | 2015-11-24T18:58:17Z | |
| dc.date.available | 2015-11-24T18:58:17Z | |
| dc.identifier.issn | 0007-0920 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19264 | |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Androstenedione/*analogs & derivatives/therapeutic use | en |
| dc.subject | Antineoplastic Agents/*therapeutic use | en |
| dc.subject | Aromatase Inhibitors | en |
| dc.subject | Breast Neoplasms/blood/*drug therapy/urine | en |
| dc.subject | Estrogens/*blood/urine | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Menopause | en |
| dc.subject | Middle Aged | en |
| dc.title | Plasma and urinary oestrogens in breast cancer patients on treatment with 4-hydroxyandrostenedione | en |
| heal.abstract | Plasma and urinary oestrogens were measured in nine breast cancer patients (eight postmenopausal women and one man) before and during treatment with the aromatase inhibitor 4-hydroxyandrostenedione. Urinary oestrogens were measured by using a highly specific GC-MS method. Plasma levels of oestrone, oestradiol and oestrone sulphate were suppressed by 66.6% (+/- 3.6%), 57.7% (+/- 5.1%) and 51.8% (+/- 6.4%) respectively (P < 0.005 for all). Twenty-four hour urinary excretion of total oestrogens, oestradiol, oestriol, 2-hydroxyoestrone, 16 alpha-hydroxyoestrone and the minor metabolites 16 beta- and 15 alpha-hydroxyoestrone were all suppressed by mean values ranging from 60% to 82%, (oestradiol: P < 0.025, otherwise P < 0.005). There were no significant changes in the ratios between the different plasma oestrogens. The finding of sustained plasma and urinary oestrogens at 20-40% compared to their control levels indirectly support a hypothesis of alternative oestrogen sources in postmenopausal breast cancer patients on treatment with 4-hydroxyandrostenedione. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8135918 | - |
| heal.identifier.secondary | http://www.nature.com/bjc/journal/v68/n2/pdf/bjc1993347a.pdf | - |
| heal.journalName | Br J Cancer | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1993 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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