Renal glomerular and tubular function in neonates with perinatal problems
| dc.contributor.author | Theocharis, P. | en |
| dc.contributor.author | Giapros, V. | en |
| dc.contributor.author | Tsampoura, Z. | en |
| dc.contributor.author | Basioti, M. | en |
| dc.contributor.author | Andronikou, S. | en |
| dc.date.accessioned | 2015-11-24T18:54:19Z | |
| dc.date.available | 2015-11-24T18:54:19Z | |
| dc.identifier.issn | 1476-4954 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18671 | |
| dc.rights | Default Licence | - |
| dc.subject | Female | en |
| dc.subject | Gestational Age | en |
| dc.subject | Greece/epidemiology | en |
| dc.subject | Humans | en |
| dc.subject | Incidence | en |
| dc.subject | Infant, Newborn | en |
| dc.subject | Infant, Premature | en |
| dc.subject | Infant, Premature, Diseases/*epidemiology | en |
| dc.subject | Intensive Care, Neonatal | en |
| dc.subject | Kidney Function Tests | en |
| dc.subject | Logistic Models | en |
| dc.subject | Male | en |
| dc.subject | Renal Insufficiency/*epidemiology | en |
| dc.subject | Retrospective Studies | en |
| dc.subject | Risk Factors | en |
| dc.title | Renal glomerular and tubular function in neonates with perinatal problems | en |
| heal.abstract | OBJECTIVE: To investigate perinatal risk factors that may be associated with impaired renal function during the first 2 weeks of life. METHODS: The case notes of 150 neonates of gestational age (GA) 34-36 weeks and 494 of GA > 36 weeks were studied. Clinical risk factors were retrieved, along with indices of renal function: serum creatinine (SeCr), fractional excretion (FE) of sodium (FENa) and potassium (FEK), and the urinary calcium to creatinine ratio (UCa/UCr). Associations were identified by multiple and logistic regression analysis. RESULTS: In infants with GA > 36 weeks, raised SeCr was related to perinatal stress, odds ratio (OR): 1.9, confidence interval (CI): 1.2-2.9, p < 0.05, and to duration of treatment with aminoglycosides (AGs) (t = 2.4, p < 0.01); FEK was associated with jaundice (t = -3.1, p < 0.01), and FENa with duration of AGs treatment (t = 2.6, p < 0.01). Full-term neonates with both hypoxic-ischemic encephalopathy (HIE) and AGs administration had an 80% increase in OR for impaired SeCr levels. In infants of GA 34-36 weeks, SeCr was related to perinatal stress (OR: 9, CI: 1.3-38, p < 0.05), FEK to jaundice (t = -2.1, p < 0.05), and FENa to duration of AGs administration (t = 2.2, p < 0.05) and antenatal steroid treatment (OR: 0.8, CI: 0.6-0.95, p < 0.05). CONCLUSION: In neonates, renal impairment, being multifactorial in origin, may be caused by the additive effect of different perinatal factors. The strong negative relationship observed between jaundice and K excretion merits further investigation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.3109/14767058.2010.482602 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20569166 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.3109/14767058.2010.482602 | - |
| heal.journalName | J Matern Fetal Neonatal Med | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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