Organotin-drug interactions. Organotin adducts of tenoxicam: Synthesis and characterization of the first organotin complex of tenoxicam
| dc.contributor.author | Demertzis, M. A. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Koutsodimou, A. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.date.accessioned | 2015-11-24T16:43:40Z | |
| dc.date.available | 2015-11-24T16:43:40Z | |
| dc.identifier.issn | 0018-019X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8724 | |
| dc.rights | Default Licence | - |
| dc.subject | hydrogen-bond | en |
| dc.subject | copper(ii) | en |
| dc.subject | diclofenac | en |
| dc.subject | crystal | en |
| dc.subject | manganese(ii) | en |
| dc.subject | cobalt(ii) | en |
| dc.subject | nickel(ii) | en |
| dc.subject | contacts | en |
| dc.subject | tin(iv) | en |
| dc.subject | oxicams | en |
| dc.title | Organotin-drug interactions. Organotin adducts of tenoxicam: Synthesis and characterization of the first organotin complex of tenoxicam | en |
| heal.abstract | The synthesis and spectral characterization of the novel organotin complexes [SnBu2(ten)] (1) and [SnBu2(Hten)(2)] (2) or the potent and widely used anti-inflammatory drug tenoxicam (H(2)ten) are reported. A crystal-structure determination of 1 showed that, in this complex, the ligand is doubly deprotonated at the hydroxy O-atom and the amide N atom and is coordinated to the SnBu2 fragment via four- and six-membered chelate rings. An extended network of Sn - O - Sn, C - H ... O and C - H ... pi contacts lead to aggregation and a supramolecular assembly. Potentiometric titrations in nonaqueous solutions support the ionization of the drug by removal of the second H-atom, the amide H-atom, in the presence of thr diorganotin(IV) fragment. The K-a values of the poorly H2O-soluble drug tenoxicam were obtained spectrophotometrically in aqueous solutions of constant ionic strength. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/1522-2675(20001004)83:10<2787::AID-HLCA2787>3.0.CO;2-6 | - |
| heal.identifier.secondary | <Go to ISI>://000165167800012 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/1522-2675(20001004)83:10<2787::AID-HLCA2787>3.0.CO;2-6/asset/2787_ftp.pdf?v=1&t=h0dul77i&s=9b6d1579647760935d67e4c2529c18ea8b6406ce | - |
| heal.journalName | Helvetica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2000 | - |
| heal.publisher | Wiley | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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