Peripherin expression in hippocampal neurons induced by muscle soluble factor(s)

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dc.contributor.authorDjabali, K.en
dc.contributor.authorZissopoulou, A.en
dc.contributor.authorde Hoop, M. J.en
dc.contributor.authorGeorgatos, S. D.en
dc.contributor.authorDotti, C. G.en
dc.date.accessioned2015-11-24T18:59:28Z
dc.date.available2015-11-24T18:59:28Z
dc.identifier.issn0021-9525-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19375
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBase Sequenceen
dc.subjectCell Differentiationen
dc.subjectCells, Cultureden
dc.subjectCulture Media, Conditioneden
dc.subjectEpithelium/physiologyen
dc.subjectFetusen
dc.subjectGene Expression Regulationen
dc.subjectGrowth Inhibitors/physiologyen
dc.subjectGrowth Substances/isolation & purification/*physiologyen
dc.subjectHippocampus/cytology/drug effects/*metabolismen
dc.subject*Interleukin-6en
dc.subjectIntermediate Filament Proteins/*biosynthesisen
dc.subjectLeukemia Inhibitory Factoren
dc.subjectLymphokines/physiologyen
dc.subject*Membrane Glycoproteinsen
dc.subjectMitosis/physiologyen
dc.subjectMolecular Sequence Dataen
dc.subjectMuscles/cytology/*physiologyen
dc.subject*Nerve Tissue Proteinsen
dc.subjectNeuroglia/physiologyen
dc.subjectNeurons/cytology/drug effects/*metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.titlePeripherin expression in hippocampal neurons induced by muscle soluble factor(s)en
heal.abstractPrevious studies have shown that neuronal cells in culture can switch neurotransmitters when grown in the presence of different target cells. To examine whether this plasticity extends to structural proteins, we cocultured hippocampal neurons and pituitary-derived neuroendocrine (AtT20) cells with astrocytes, kidney epithelial cells, or skeletal muscle cells. As a marker of phenotypic change we used the cytoskeletal protein peripherin, a type III intermediate filament (IF) subunit which is not expressed in hippocampal neurons and AtT20 cells. We show here that soluble factor(s) secreted specifically from skeletal muscle cells can induce the expression and de novo assembly of peripherin in a subset of post-mitotic neurons. We further demonstrate that one of these factors is the Leukemia Inhibitory Factor/Cholinergic Neuronal Differentiation Factor. The environmentally regulated expression of peripherin implies a remarkable degree of plasticity in the cytoskeletal organization of postmitotic CNS cells and provides a noninvasive model system to examine the de novo assembly of IF proteins under in vivo conditions.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8245126-
heal.identifier.secondaryhttp://jcb.rupress.org/content/123/5/1197.full.pdf-
heal.journalNameJ Cell Biolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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