High inflammation and mild demyelination in the peripheral nervous system induced by an intraneural injection of RR interleukin-4
| dc.contributor.author | Deretzi, G. | en |
| dc.contributor.author | Pelidou, S. H. | en |
| dc.contributor.author | Zou, L. P. | en |
| dc.contributor.author | Wei, L. | en |
| dc.contributor.author | Nennesmo, I. | en |
| dc.contributor.author | Zhu, J. | en |
| dc.date.accessioned | 2015-11-24T19:13:48Z | |
| dc.date.available | 2015-11-24T19:13:48Z | |
| dc.identifier.issn | 1043-4666 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21227 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Demyelinating Diseases/chemically induced/immunology/*pathology | en |
| dc.subject | Histocompatibility Antigens Class II/analysis | en |
| dc.subject | Inflammation | en |
| dc.subject | Interleukin-4/*toxicity | en |
| dc.subject | Nerve Fibers/pathology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Lew | en |
| dc.subject | Recombinant Proteins/*toxicity | en |
| dc.subject | Sciatic Nerve/drug effects/immunology/*pathology | en |
| dc.subject | Time Factors | en |
| dc.title | High inflammation and mild demyelination in the peripheral nervous system induced by an intraneural injection of RR interleukin-4 | en |
| heal.abstract | To examine the direct effects of IL-4 on peripheral nervous system (PNS) we injected recombinant rat IL-4 (rrIL-4) into the sciatic nerve of normal adult Lewis rats. Histopathological and immunohistochemical observations revealed that 1 day after injection, a large number of macrophages and MHC class II-positive cells appeared within both the perineurium and endoneurium. Only few CD4(+)and CD8(+)T cells existed in the endoneurium. From day 4 to day 7, we observed a gradual decline of inflammation, but the number of infiltrates in rrIL-4 injected nerves was significantly higher compared with sterile PBS-injected control group. On the contrary, demyelination affected significantly fewer nerve fibres in the rrIL-4-injected nerves compared with control group on day 7. Intraneural injection of rrIL-4 results in high grade inflammation and mild demyelination in the PNS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1006/cyto.1999.0613 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10843769 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S1043466699906130/1-s2.0-S1043466699906130-main.pdf?_tid=b42eb74aff8542d58445be2c330811a5&acdnat=1332844608_f2d6ac1987f0a08f5c0a4cf954a35d4d | - |
| heal.journalName | Cytokine | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2000 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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