Stress modulates the enzymatic inducibility by benzo[alpha]pyrene in the rat liver
Φόρτωση...
Ημερομηνία
Συγγραφείς
Konstandi, M.
Johnson, E.
Lang, M. A.
Camus-Radon, A. M.
Marselos, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pharmacol Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The role of stress on the inducibility by benzo[alpha]pyrene (B[alpha]P), a representative polycyclic aromatic hydrocarbon, of several drug-metabolizing enzymes was investigated in rats, using restraint stress and mild unpredictable stress as models of psychological stress. Restraint stress was found to significantly suppress basal ethoxyresorufin 7-dealkylase (EROD) and pentoxyresorufin 7-dealkylase (PROD) activities (two-fold). In contrast, mild unpredictable stress markedly increased basal EROD activity, while PROD activity was not affected. In addition, both types of stress resulted in a significant reduction of basal p -nitrophenol hydroxylation (PNP). It is worth noting that restraint stress greatly enhanced the inducibility of EROD, methoxyresorufin 7-dealkylase (MROD) and to a lesser extent PROD activities by B[alpha]P, while mild unpredictable stress had no, or only a mild effect on the inducibility of cytochrome P450s (CYPs) by B[alpha]P. In conclusion, psychological stress may modulate different enzymatic systems which are vital elements of the detoxification mechanisms of the body. The two distinct types of psychological stress used in this study appear to affect the enzymatic systems under investigation in a stress-specific manner at the basal level and at the induced state by B[alpha]P.
Περιγραφή
Λέξεις-κλειδιά
Animals, Benzo(a)pyrene/*pharmacology, Cytochrome P-450 CYP1A1/biosynthesis, Cytochrome P-450 CYP2B1/biosynthesis, Enzyme Induction/drug effects, Liver/*enzymology, Male, Rats, Rats, Wistar, Stress, Physiological/*enzymology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10945924
http://ac.els-cdn.com/S1043661800906753/1-s2.0-S1043661800906753-main.pdf?_tid=0e2503608b403faf352dfb9b7ff07087&acdnat=1332759603_1d478bdab8323eae2d2024803eb664dd
http://ac.els-cdn.com/S1043661800906753/1-s2.0-S1043661800906753-main.pdf?_tid=0e2503608b403faf352dfb9b7ff07087&acdnat=1332759603_1d478bdab8323eae2d2024803eb664dd
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής