Neuroendocrine carcinoma of unknown primary: a systematic review of the literature and a comparative study with other neuroendocrine tumors
| dc.contributor.author | Stoyianni, A. | en |
| dc.contributor.author | Pentheroudakis, G. | en |
| dc.contributor.author | Pavlidis, N. | en |
| dc.date.accessioned | 2015-11-24T19:02:17Z | |
| dc.date.available | 2015-11-24T19:02:17Z | |
| dc.identifier.issn | 1532-1967 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19785 | |
| dc.rights | Default Licence | - |
| dc.subject | Carcinoma, Neuroendocrine/*mortality/*pathology/therapy | en |
| dc.subject | Combined Modality Therapy | en |
| dc.subject | Disease-Free Survival | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Neoplasm Invasiveness/pathology | en |
| dc.subject | Neoplasm Staging | en |
| dc.subject | Neoplasms, Unknown Primary/*mortality/*pathology/therapy | en |
| dc.subject | Prognosis | en |
| dc.subject | Risk Assessment | en |
| dc.subject | Survival Analysis | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Neuroendocrine carcinoma of unknown primary: a systematic review of the literature and a comparative study with other neuroendocrine tumors | en |
| heal.abstract | INTRODUCTION: Neuroendocrine carcinomas of unknown primary (NCUP) represent a specific subset with relatively favorable prognosis. Data on biology, management and outcome of NCUP patients have not been systematically reviewed neither compared to those of neuroendocrine tumors of known primary. PATIENTS AND METHODS: We systematically reviewed all publications studying neuroendocrine CUP patients and presented a single center retrospective patient series. In addition, we analyzed and specified the similarities and/or differences between NCUP and other neuroendocrine malignancies. RESULTS: Five hundred patients with NCUP constituted a heterogeneous cohort in terms of histology, grade, anatomic site and tumor biology in published series and were managed mostly with platinum-based regimens. Among 294 patients with available outcome data, a median survival of 15.5 months (range 11.6-40) was observed. Comparative analysis with neuroendocrine solid tumors (NET) revealed that poorly-differentiated NCUP share an aggressive natural history and a dismal prognosis similar to high grade pulmonary and extrapulmonary neuroendocrine carcinomas (Large Cell Neuroendocrine bronchial Carcinomas, LCNEC and poorly differentiated gastroenteropancreatic tumors, GEP-NET). Well differentiated NCUP reveal a more indolent course with a survival range resembling that of typical and atypical pulmonary carcinoids, well differentiated gastrointestinal NETs and limited small cell lung carcinomas. CONCLUSION: No evidence for distinct biology or outcome of NCUP patients emerged when histological grade was matched for known primary NETs. The high heterogeneity of the NCUP subgroup limits the potential for identification of reliable prognosticators and hinders development of novel targeted therapies. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.ctrv.2011.03.002 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21481536 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0305737211000429/1-s2.0-S0305737211000429-main.pdf?_tid=31d024ffe75bd670e4a4a883cda09eea&acdnat=1333955164_0d054e2475f3e0a941d82f13bbdefc95 | - |
| heal.journalName | Cancer Treat Rev | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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