Strong association of interleukin-6 -174 G>C promoter polymorphism with increased risk of oral cancer

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dc.contributor.authorVairaktaris, E.en
dc.contributor.authorYiannopoulos, A.en
dc.contributor.authorVylliotis, A.en
dc.contributor.authorYapijakis, C.en
dc.contributor.authorDerka, S.en
dc.contributor.authorVassiliou, S.en
dc.contributor.authorNkenke, E.en
dc.contributor.authorSerefoglou, Z.en
dc.contributor.authorRagos, V.en
dc.contributor.authorTsigris, C.en
dc.contributor.authorVorris, E.en
dc.contributor.authorCritselis, E.en
dc.contributor.authorAvgoustidis, D.en
dc.contributor.authorNeukam, F. W.en
dc.contributor.authorPatsouris, E.en
dc.date.accessioned2015-11-24T18:50:26Z
dc.date.available2015-11-24T18:50:26Z
dc.identifier.issn0393-6155-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18069
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInterleukin-6/*geneticsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMouth Neoplasms/etiology/*geneticsen
dc.subject*Polymorphism, Geneticen
dc.subject*Promoter Regions, Geneticen
dc.titleStrong association of interleukin-6 -174 G>C promoter polymorphism with increased risk of oral canceren
heal.abstractIn view of the recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of interleukin-6 (IL-6) with an increased risk of oral cancer. In DNA samples of 162 patients with oral squamous cell carcinoma and 156 healthy controls of comparable ethnicity, age and sex, we studied the -174 G>C polymorphism in the IL-6 gene, which affects its transcription. C allele frequencies were significantly increased in patients compared to controls, 42.6% versus 23.1% (p<0.001). The CC homozygotes had a 7-fold greater risk of developing oral cancer (odds ratio 7.39, 95% CI 2.61-20.92), while the GC heterozygotes had a 4-fold greater risk (odds ratio 3.74, 95% CI 2.29-6.11). A significant increase in C alleles was observed in patients regardless of their smoking or alcohol consumption habits, early or advanced stage of cancer, and presence or absence of a family history for cancer or thrombophilia (p<0.001; Fisher's exact test). These findings suggest that the -174 G>C polymorphism, by affecting IL-6 gene expression, is strongly associated with oral oncogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17177164-
heal.journalNameInt J Biol Markersen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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