Serum osteoprotegerin, RANKL and fibroblast growth factor-23 in children with chronic kidney disease
Φόρτωση...
Ημερομηνία
Συγγραφείς
Siomou, E.
Challa, A.
Printza, N.
Giapros, V.
Petropoulou, F.
Mitsioni, A.
Papachristou, F.
Stefanidis, C. J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pediatr Nephrol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Osteoprotegerin (OPG), receptor activator of the nuclear factor kappaB ligand (RANKL) and fibroblast growth factor-23 (FGF-23) play a central role in renal osteodystrophy. We evaluated OPG/RANKL and FGF-23 levels in 51 children with chronic kidney disease (CKD) [n = 26 stage 3 or 4 (CKD3-4) and n = 25 stage 5 (CKD5)] and 61 controls. Any possible association with intact parathyroid hormone (iPTH) and bone turnover markers was also investigated. The OPG levels were lower in the CKD3-4 group (p < 0.001) and higher in the CKD5 group (p < 0.01) than in the controls, while RANKL levels did not differ. The FGF-23 levels were higher in both patient groups (p < 0.0001), while the levels of phosphate and iPTH were higher only in the CKD5 group (p < 0.0001). There were independent positive correlations between OPG and RANKL (beta = 0.297, p < 0.01) and FGF-23 (beta = 0.352, p < 0.05) and a negative correlation with the bone resorption marker TRAP5b (beta = -0.519, p < 0.001). OPG was positively correlated with iPTH (R = 0.391, p < 0.01). An independent positive correlation between FGF-23 and phosphate (beta = 0.368, p < 0.05) or iPTH (beta = 0.812, p < 0.0001) was noted. In conclusion, we found that higher OPG levels in patients with CKD stage 5 correlated with the levels of RANKL, FGF-23, iPTH, and TRAP5b. These findings may reflect a compensatory mechanism to the negative balance of bone turnover. High FGF-23 levels in early CKD stages may indicate the need for intervention to manage serum phosphate (Pi) levels.
Περιγραφή
Λέξεις-κλειδιά
Acid Phosphatase/blood, Analysis of Variance, Biological Markers/blood, Bone Remodeling, Case-Control Studies, Child, Child, Preschool, Chronic Disease, Female, Fibroblast Growth Factors/*blood, Greece, Humans, Isoenzymes/blood, Kidney Diseases/*blood/diagnosis/physiopathology, Male, Osteoprotegerin/*blood, Parathyroid Hormone/blood, Phosphates/blood, RANK Ligand/*blood, Regression Analysis, Severity of Illness Index
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21479768
http://www.springerlink.com/content/n630rn43h3464v6g/fulltext.pdf
http://www.springerlink.com/content/n630rn43h3464v6g/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής