Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population
Loading...
Date
Authors
Markoula, S.
Chatzikyriakidou, A.
Giannopoulos, S.
Odysseas, K.
Markou, S.
Vemmos, K.
Georgiou, I.
Kyritsis, A. P.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Stroke Res Treat
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFalpha-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls (P = .008, OR = 2.47 (1.26-4.84), P = .005, OR = 1.97 (1.22-3.17), and P = .003, OR = 2.2 (1.43-3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls (P = .009, OR = 1.48 (1.1-2) and P = .001, OR = 1.75 (1.25-2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.
Description
Keywords
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/21776368
http://downloads.hindawi.com/journals/srt/2011/920584.pdf
http://downloads.hindawi.com/journals/srt/2011/920584.pdf
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής