Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

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dc.contributor.authorYu, Y.en
dc.contributor.authorBhangale, T. R.en
dc.contributor.authorFagerness, J.en
dc.contributor.authorRipke, S.en
dc.contributor.authorThorleifsson, G.en
dc.contributor.authorTan, P. L.en
dc.contributor.authorSouied, E. H.en
dc.contributor.authorRichardson, A. J.en
dc.contributor.authorMerriam, J. E.en
dc.contributor.authorBuitendijk, G. H.en
dc.contributor.authorReynolds, R.en
dc.contributor.authorRaychaudhuri, S.en
dc.contributor.authorChin, K. A.en
dc.contributor.authorSobrin, L.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorLee, P. H.en
dc.contributor.authorLee, A. Y.en
dc.contributor.authorLeveziel, N.en
dc.contributor.authorZack, D. J.en
dc.contributor.authorCampochiaro, B.en
dc.contributor.authorCampochiaro, P.en
dc.contributor.authorSmith, R. T.en
dc.contributor.authorBarile, G. R.en
dc.contributor.authorGuymer, R. H.en
dc.contributor.authorHogg, R.en
dc.contributor.authorChakravarthy, U.en
dc.contributor.authorRobman, L. D.en
dc.contributor.authorGustafsson, O.en
dc.contributor.authorSigurdsson, H.en
dc.contributor.authorOrtmann, W.en
dc.contributor.authorBehrens, T. W.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorvan Duijn, C. M.en
dc.contributor.authorVingerling, J. R.en
dc.contributor.authorKlaver, C. C. W.en
dc.contributor.authorAllikmets, R.en
dc.contributor.authorBrantley, M. A.en
dc.contributor.authorBaird, P. N.en
dc.contributor.authorKatsanis, N.en
dc.contributor.authorThorsteinsdottir, U.en
dc.contributor.authorIoannidis, J. P. A.en
dc.contributor.authorDaly, M. J.en
dc.contributor.authorGraham, R. R.en
dc.contributor.authorSeddon, J. M.en
dc.date.accessioned2015-11-24T18:31:34Z
dc.date.available2015-11-24T18:31:34Z
dc.identifier.issn0964-6906-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/16490
dc.rightsDefault Licence-
dc.subjectgenome-wide associationen
dc.subjectcomplement factor-hen
dc.subjectgenetic-associationen
dc.subjectrisken
dc.subjectsusceptibilityen
dc.subjectmetaanalysisen
dc.subjecthaplotypeen
dc.subjectdiseaseen
dc.subjectlocien
dc.subjectangiogenesisen
dc.titleCommon variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degenerationen
heal.abstractDespite significant progress in the identification of genetic loci for age-related macular degeneration (AMD), not all of the heritability has been explained. To identify variants which contribute to the remaining genetic susceptibility, we performed the largest meta-analysis of genome-wide association studies to date for advanced AMD. We imputed 6 036 699 single-nucleotide polymorphisms with the 1000 Genomes Project reference genotypes on 2594 cases and 4134 controls with follow-up replication of top signals in 5640 cases and 52 174 controls. We identified two new common susceptibility alleles, rs1999930 on 6q21-q22.3 near FRK/COL10A1 [odds ratio (OR) 0.87; P = 1.1 x 10(-8)] and rs4711751 on 6p12 near VEGFA (OR 1.15; P = 8.7 x 10(-9)). In addition to the two novel loci, 10 previously reported loci in ARMS2/HTRA1 (rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), LIPC (rs10468017), TIMP3 (rs9621532) and CETP (rs3764261) were confirmed with genome-wide significant signals in this large study. Loci in the recently reported genes ABCA1 and COL8A1 were also detected with suggestive evidence of association with advanced AMD. The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1093/Hmg/Ddr270-
heal.identifier.secondary<Go to ISI>://000294442200016-
heal.identifier.secondaryhttp://hmg.oxfordjournals.org/content/20/18/3699.full.pdf-
heal.journalNameHum Mol Geneten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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