An observational study of women with positive HPV-DNA tests and normal cytology and colposcopy

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dc.contributor.authorParaskevaidis, E.en
dc.contributor.authorDavidson, E. J.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorHirsch, P. M.en
dc.contributor.authorPappa, L.en
dc.contributor.authorKoliopoulos, G.en
dc.contributor.authorLolis, E.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorPaschopoulos, M.en
dc.contributor.authorDoussias, V.en
dc.contributor.authorAgnantis, N.en
dc.date.accessioned2015-11-24T19:36:28Z
dc.date.available2015-11-24T19:36:28Z
dc.identifier.issn0392-2936-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23884
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectColposcopy/*standardsen
dc.subjectDNA, Viral/*isolation & purificationen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectPapillomaviridae/*genetics/isolation & purificationen
dc.subjectPapillomavirus Infections/diagnosis/*virologyen
dc.subjectPredictive Value of Testsen
dc.subjectRetrospective Studiesen
dc.subjectTumor Virus Infections/diagnosis/*virologyen
dc.subjectUterine Cervical Neoplasms/diagnosis/*virologyen
dc.subjectVaginal Smearsen
dc.titleAn observational study of women with positive HPV-DNA tests and normal cytology and colposcopyen
heal.abstractPURPOSE: High risk human papillomaviruses (HPV) are implicated in the aetiology of malignant cervical disease. The usefulness of HPV DNA tests in identifying women at risk of cervical cancer as an adjunct to cervical cytology is under evaluation. Patients and METHODS: This is a retrospective analysis of 47 women positive for high risk HPV but with negative cytology and negative colposcopy at the start of the study. Women were observed for three years or more (in 96% cases) using six-monthly combined HPV DNA tests, cytological and colposcopic evaluation. RESULTS: At the end of follow-up, 29/47 (62%) women were still positive for high risk HPV, 45/47 (96%) women had normal cytology and 47/47 (100%) women continued to have normal colposcopy. CONCLUSIONS: Normal colposcopy has an excellent negative predictive value for HPV positive women with normal cytology. These women can be safely screened cytologically on a three-yearly basis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12214732-
heal.journalNameEur J Gynaecol Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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