Levodopa-induced dyskinesia and rotational behavior in hemiparkinsonian rats: independent features or components of the same phenomenon?
| dc.contributor.author | Konitsiotis, S. | en |
| dc.contributor.author | Tsironis, C. | en |
| dc.date.accessioned | 2015-11-24T19:07:20Z | |
| dc.date.available | 2015-11-24T19:07:20Z | |
| dc.identifier.issn | 0166-4328 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20425 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Antiparkinson Agents/*adverse effects | en |
| dc.subject | Behavior, Animal | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Dyskinesia, Drug-Induced/*etiology/*physiopathology | en |
| dc.subject | Levodopa/*adverse effects | en |
| dc.subject | Male | en |
| dc.subject | Oxidopamine/toxicity | en |
| dc.subject | Parkinsonian Disorders/chemically induced/*drug therapy | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | *Rotation | en |
| dc.subject | Time Factors | en |
| dc.title | Levodopa-induced dyskinesia and rotational behavior in hemiparkinsonian rats: independent features or components of the same phenomenon? | en |
| heal.abstract | Chronic daily administration of 6.25mg/kg of levodopa in unilaterally 6-OHDA lesioned rats did not induce any observable behavioral effects for the first 12.5+/-2.5 days. Thereafter, levodopa administration induced abnormal involuntary movements (AIMs), involving the contralateral limb, head, neck and trunk, along with the development of contralateral rotations. AIMs and rotations followed a progressively worsening, highly correlated, parallel course. We suggest that rotational behavior does not represent a pure antiparkinsonian response, but along with levodopa-induced dyskinesia is part of the levodopa-induced motor response complications syndrome. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.bbr.2006.02.030 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16621050 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0166432806001409/1-s2.0-S0166432806001409-main.pdf?_tid=7f28d0ff192fda0d71bdc121ca1ba1d0&acdnat=1332840481_4dd83507353874291b86e6c6cbbb73db | - |
| heal.journalName | Behav Brain Res | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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