Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone with potential biological activity. Synthesis, structure and spectral properties. Extended network via hydrogen bond linkages of [Pd(PyTsc)Cl]
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Miller, J. R. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.date.accessioned | 2015-11-24T16:43:54Z | |
| dc.date.available | 2015-11-24T16:43:54Z | |
| dc.identifier.issn | 0277-5387 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8751 | |
| dc.rights | Default Licence | - |
| dc.subject | palladium(ii) and platinum(ii) complexes | en |
| dc.subject | thiosemicarbazonato complexes | en |
| dc.subject | crystal study | en |
| dc.subject | spectroscopic and electrochemical studies | en |
| dc.subject | antitumor-activity | en |
| dc.subject | metal-complexes | en |
| dc.subject | in-vitro | en |
| dc.subject | 2-acetylpyridine | en |
| dc.subject | electrochemistry | en |
| dc.subject | derivatives | en |
| dc.subject | antifungal | en |
| dc.subject | copper | en |
| dc.subject | pd(ii) | en |
| dc.title | Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone with potential biological activity. Synthesis, structure and spectral properties. Extended network via hydrogen bond linkages of [Pd(PyTsc)Cl] | en |
| heal.abstract | The reactions of Li2PdCl4 and Na2PtCl4 with pyridine-2-carbaldehyde thiosemicarbazone, HPyTsc, afforded the complexes [Pd(PyTsc)Cl], [Pd(PyTsc)(2)] and [Pt(PyTsc)Cl], [Pt(PyTsc)(2)]. The new complexes have been characterized by elemental analyses and spectroscopic studies. A crystal structure of [Pd(PyTsc)Cl] shows that the anion of PyTsc coordinates in a planar conformation to the central palladium(II) through the pyridyl N, azomethine N and thiolato S atoms. The planar molecules are linked into polymeric chains by N-(HN)-N-.. and N-(HS)-S-.. hydrogen bonding. The protonation constants of the ligand. K-a1 and K-a2, were determined by spectrophotometry and the logarithms of their values were found to be equal to 11.58+/-0.05 and 3.94+/-0.02 respectively. Correlation of the antitumor activity of these complexes to the structure and to reduction potential is reported. The compounds [Pt(PyTsc)(2)] and [Pd(PyTsc)(2)] were found to exhibit the higher in vivo antitumor activity and the lower cytotoxicity. (C) 1999 Elsevier Science Ltd. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000080231900011 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0277538798003866/1-s2.0-S0277538798003866-main.pdf?_tid=44012329e8ab38d5568d70362e344b71&acdnat=1333028795_89548d7336bdc126ac0fb55386587230 | - |
| heal.journalName | Polyhedron | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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