Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction

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dc.contributor.authorMitsi, A. C.en
dc.contributor.authorHatzistergos, K. E.en
dc.contributor.authorNiokou, D.en
dc.contributor.authorPappa, L.en
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorTsalikakis, D. G.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorKolettis, T. M.en
dc.date.accessioned2015-11-24T19:23:18Z
dc.date.available2015-11-24T19:23:18Z
dc.identifier.issn1096-6374-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22277
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntihypertensive Agents/administration & dosageen
dc.subjectCaptopril/administration & dosageen
dc.subjectDisease Models, Animalen
dc.subjectGrowth Hormone/*administration & dosage/*metabolismen
dc.subjectHumansen
dc.subjectMyocardial Infarction/*metabolism/pathologyen
dc.subjectNeovascularization, Pathologic/*chemically induced/metabolism/pathologyen
dc.subjectSwineen
dc.subjectVentricular Remodeling/*drug effectsen
dc.titleEarly, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarctionen
heal.abstractOBJECTIVE: Ventricular remodeling is a common corollary of myocardial infarction. We hypothesized that this process may be attenuated by growth hormone, administered as a single high-dose, selectively in the infarct zone, early postmyocardial infarction. DESIGN: In 35 pigs (29+/-4 kg), myocardial infarction was generated by inflation of an over-the-wire angioplasty balloon in the circumflex artery for 60 min and 5 further pigs were sham-operated. Ten minutes after reperfusion, the pigs were randomized (2:1) to either growth hormone (1 IU/kg) (n=23) or normal saline (n=12), delivered via the balloon catheter. All survivors were treated with captopril and were sacrificed 4 weeks after myocardial infarction. RESULTS: Compared to controls, growth hormone-treated animals displayed lower heart weight (4.1+/-0.5 g/kg body weight, versus 3.4+/-0.4 g/kg, respectively, p=0.003) and dimensions (left ventricular short axis diameter 46+/-7 mm versus 37+/-6 mm, p=0.01; right ventricular short axis diameter 38+/-7 mm versus 30+/-5 mm p=0.001). Growth hormone increased wall thickness in the infarct (6.0+/-1.8 in controls versus 9.9+/-3.7 in treated animals, p=0.004) and non-infarct zones (10.6+/-1.8 in controls versus 15.5+/-3.8 in treated animals, p=0.0006) and produced higher (p<0.05) microvascular density in both zones. CONCLUSION: Intracoronary administration of growth hormone attenuates left and right ventricular remodeling by inducing hypertrophy and by enhancing angiogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ghir.2006.02.001-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16624608-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1096637406000220/1-s2.0-S1096637406000220-main.pdf?_tid=34e29a5e2e9d33dfe71d8a7f25b84a5a&acdnat=1333700099_2ba55f39377fc1c9d8c4b055ca97ea1a-
heal.journalNameGrowth Horm IGF Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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