Freeze lesion-induced focal cortical dysplasia predisposes to atypical hyperthermic seizures in the immature rat

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dc.contributor.authorScantlebury, M. H.en
dc.contributor.authorOuellet, P. L.en
dc.contributor.authorPsarropoulou, C.en
dc.contributor.authorCarmant, L.en
dc.date.accessioned2015-11-24T16:33:26Z
dc.date.available2015-11-24T16:33:26Z
dc.identifier.issn0013-9580-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7659
dc.rightsDefault Licence-
dc.subjectneuronal migration disorderen
dc.subjectpolymicrogyriaen
dc.subjecthyperthermiaen
dc.subjectepilepsyen
dc.subjectfebrile seizuresen
dc.subjectfreeze lesionen
dc.subjectneuronal migration disordersen
dc.subjecttemporal-lobe epilepsyen
dc.subjectfebrile seizuresen
dc.subjectneocortical structuresen
dc.subjectdual pathologyen
dc.subjectdevelopmental malformationsen
dc.subjectcerebral men
dc.titleFreeze lesion-induced focal cortical dysplasia predisposes to atypical hyperthermic seizures in the immature raten
heal.abstractPurpose: To determine the effects of focal cortical dysplasia on the behavioral and electrographic features of hyperthermia-induced seizures (HSs) in rats. Methods: A right sensorimotor cortex freeze lesion was induced in postnatal day 1 (P1) rat pups, and HSs were provoked at P10 under continuous monitoring of core temperatures EEGs were recorded from the right amygdala during and after hyperthermia. Controls included both sham-operated at PI and naive rats. Results: HSs began with jaw myoclonus, followed by hindlimb clonus and generalized convulsions (GCs), and terminated by a period of posthyperthermia depression. The threshold temperature and latency of jaw myoclonus were similar across the groups. However, both the threshold temperature and latency of GCs were significantly lower in lesioned pups than in controls (40.5 +/- 0.5degreesC, n = 24, vs. 42.0 +/- 0.2degreesC, n = 2 1; p < 0.001; 6.7 &PLUSMN; 0.6 min, n = 20, vs. 8.4 &PLUSMN; 0.6 min, n = 22; p < 0.05). In lesioned pups, the threshold and latencies for jaw myoclonus and hindlimb clonus were similar, whereas in controls, the progression from one to the other was marked by significant differences in both parameters. Posthyperthermia depression was longer in lesioned (13.3 +/- 1.2 min, n = 21) than in control (8.0 +/- 0.8 min, n = 20; p < 0.0001) pups. Ictal EEG activity was recorded during both behavioral seizures and posthyperthermia depression. Conclusions: An HS in rats with a localized freeze lesion results in lower threshold GC and prolonged ictal manifestations, thus supporting a pathophysiologic link between focal cortical dysplasia and atypical febrile seizures, conditions that have a high prevalence in children with mesial temporal lobe epilepsy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000221992900004-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.0013-9580.2004.51503.x/asset/j.0013-9580.2004.51503.x.pdf?v=1&t=hfxnti77&s=0dfeccca4d1289bd4cef146192040a68a53d9933-
heal.journalNameEpilepsiaen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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