UV-VIS spectral information of platinum(II) and palladium(II) complexes with pyridine-2-carboxaldehyde-thiosemicarbazone and their correlation with antineoplastic and cytogenetic effects

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dc.contributor.authorSarbu, C.en
dc.contributor.authorVijdeluc, C.en
dc.contributor.authorDemertzis, M. A.en
dc.contributor.authorKovala-Demertzi, D.en
dc.date.accessioned2015-11-24T16:52:08Z
dc.date.available2015-11-24T16:52:08Z
dc.identifier.issn0034-7752-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9835
dc.rightsDefault Licence-
dc.subjectchemometricsen
dc.subjectqsaren
dc.subjectpcaen
dc.subjectuv-vis-spectraen
dc.subjectpd(ii) and pt(h) complexesen
dc.subjectpyridine-2-carbaldehyde thiosemicarbazoneen
dc.subjectprincipal component analysisen
dc.subjectthin-layer-chromatographyen
dc.subjectliquid-chromatographyen
dc.subjectantitumor-activityen
dc.subjectretention dataen
dc.subjectlipophilicityen
dc.subjectthiosemicarbazonesen
dc.subjectdescriptorsen
dc.subjectderivativesen
dc.subjectinhibitionen
dc.titleUV-VIS spectral information of platinum(II) and palladium(II) complexes with pyridine-2-carboxaldehyde-thiosemicarbazone and their correlation with antineoplastic and cytogenetic effectsen
heal.abstractIn principle, QSAR describe how the molecular structure, in terms of descriptors-lipophilic, electronic and steric - affects the chemical or biological activity of a compound. In this regard the UV-VIS spectra appear of a real interest considering their intrinsic electronic informational character As a consequence the reliability of factor scores described by the first principal components as "natural electronic descriptors" has been tested in this paper, by comparing it with biological data of Pd(H) and Pt(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone concerning their effect on sister chromatid exchange (SCE) rate and human lymphocyte proliferation kinetics (proliferation rate index; PRI) and antitumour activity on leukemia-P388-bearing mice. The high significant correlations obtained in some cases indicate a potential relevance of UV-VIS information for QSAR/QSPR studies.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000223160500002-
heal.journalNameRevista De Chimieen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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