Nasal T-cell lymphoma: a clinicopathologic entity associated with peculiar phenotype and with Epstein-Barr virus

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dc.contributor.authorKanavaros, P.en
dc.contributor.authorLescs, M. C.en
dc.contributor.authorBriere, J.en
dc.contributor.authorDivine, M.en
dc.contributor.authorGalateau, F.en
dc.contributor.authorJoab, I.en
dc.contributor.authorBosq, J.en
dc.contributor.authorFarcet, J. P.en
dc.contributor.authorReyes, F.en
dc.contributor.authorGaulard, P.en
dc.date.accessioned2015-11-24T19:02:37Z
dc.date.available2015-11-24T19:02:37Z
dc.identifier.issn0006-4971-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19818
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAntigens, CD/*analysisen
dc.subjectDNA, Viral/analysisen
dc.subjectFemaleen
dc.subjectHerpesvirus 4, Human/genetics/*isolation & purificationen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIn Situ Hybridizationen
dc.subjectLymphoma, Large B-Cell, Diffuse/pathologyen
dc.subjectLymphoma, T-Cell/immunology/microbiology/*pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNose Neoplasms/immunology/microbiology/*pathologyen
dc.subjectRNA, Viral/analysisen
dc.subjectReceptors, Antigen, T-Cell/*analysisen
dc.subjectSkin Neoplasms/immunology/microbiology/*pathologyen
dc.subjectTranscription, Geneticen
dc.titleNasal T-cell lymphoma: a clinicopathologic entity associated with peculiar phenotype and with Epstein-Barr virusen
heal.abstractRecent evidence has shown that most nasal lymphomas (NL) are associated with a T-cell phenotype and are thus called nasal T-cell lymphomas (NTCL), but little information is available about the T-cell receptor (TCR) expression. The presence of Epstein-Barr virus (EBV) genome has been recently reported in NTCL in Oriental populations in which NL and EBV-associated tumors are more common and in occasional Occidental cases. This prompted us to investigate lymphoma biopsies from 7 non-Oriental patients with NTCL for the expression of natural killer (NK) and T-cell antigens, including TCR proteins, for the presence of EBV-encoded latent membrane protein (LMP) using immunohistochemistry and for the presence of EBV DNA and Epstein-Barr early region (EBER) RNA using in situ hybridization (ISH). Six cases displayed a CD3-, TCR alpha beta-, TCR gamma delta-, CD2+, CD7+, CD5-, CD4-, CD8-, CD56+ phenotype, suggesting that these tumors may be peripheral T-cell lymphomas (PTCL) with extensive loss of T-cell antigens and expression of the NK-cell (CD56) antigen or, alternatively, NK-cell neoplasias. The remaining case was a gamma delta PTCL, as shown by the CD3+, TCR gamma delta+ phenotype and the biallelic gamma and delta TCR gene rearrangements. Using ISH, EBER RNA transcripts were detected in tumor cells in all cases and EBV DNA was shown in the 6 tested cases. In all cases, tumor cells expressed LMP. These findings support the concept that NTCL constitute a distinct group of lymphomas that, in addition to their peculiar clinical features, exhibit an unusual TCR "silent" CD56+ or TCR gamma delta+ phenotype and harbor the EBV. In view of the LMP transforming potential, these data suggest that EBV may play a role in the pathogenesis of NTCL.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8387835-
heal.journalNameBlooden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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