The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein

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dc.contributor.authorKaretsou, Z.en
dc.contributor.authorMartic, G.en
dc.contributor.authorSflomos, G.en
dc.contributor.authorPapamarcaki, T.en
dc.date.accessioned2015-11-24T19:41:11Z
dc.date.available2015-11-24T19:41:11Z
dc.identifier.issn0006-291X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24455
dc.rightsDefault Licence-
dc.subjectBiotinylationen
dc.subjectCREB-Binding Proteinen
dc.subjectCell Cycleen
dc.subjectChromosomal Proteins, Non-Histone/*chemistry/metabolismen
dc.subjectFluorescent Antibody Technique, Indirecten
dc.subjectGlutathione Transferase/metabolismen
dc.subjectHeLa Cellsen
dc.subjectHistone Chaperonesen
dc.subjectHistones/*chemistryen
dc.subjectHumansen
dc.subjectImmunoprecipitationen
dc.subjectMicroscopy, Confocalen
dc.subjectMolecular Chaperones/chemistryen
dc.subjectMutationen
dc.subjectNuclear Proteins/*chemistryen
dc.subjectPlasmids/metabolismen
dc.subjectProtein Bindingen
dc.subjectRecombinant Proteins/chemistryen
dc.subjectTrans-Activators/*chemistryen
dc.subjectTranscription Factors/*chemistry/metabolismen
dc.subjectTranscription, Geneticen
dc.subjectTranscriptional Activationen
dc.titleThe histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding proteinen
heal.abstractThe oncoprotein SET/TAF-Ibeta is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts directly with the acetyltransferase CREB-binding protein (CBP) and enhances the transactivation potential of the transcription coactivator. Our data suggest that the histone chaperone SET regulates the CBP-mediated transcription and may indicate a general principle by which transcriptional regulators cooperate with histone chaperones for gene activation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.bbrc.2005.06.210-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16061203-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0006291X05014026/1-s2.0-S0006291X05014026-main.pdf?_tid=e3da90684ae4d745599aa9ffd25cacc2&acdnat=1332915815_05e040e356c50e5eefc9decac00a6664-
heal.journalNameBiochem Biophys Res Communen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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