Mydj2 as a potent partner of hsc70 in mammalian cells
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bozidis, P.
Lazaridis, I.
Pagoulatos, G. N.
Angelidis, C. E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Dj2 is a member of the DnaJ family of proteins, which regulate the chaperoning function of the hsp70s. We isolated a monkey cDNA dj2 clone corresponding to the large mRNA species encoded by the gene. This mRNA differs from the small mRNA produced by the same gene in that it contains a long 3' untranslated region. Both messages were found to be equally stable and to produce the same protein, which is susceptible to farnesylation. Studies in mouse tissues and various cell lines revealed that these messages and their products are differentially expressed. Surprisingly, we found that only the nonfarnesylated form of dj2 is capable of translocating to the cell nucleus, especially after heat shock. Finally, based on protein interaction studies, our results indicate that dj2 is a specific partner for hsc70 and not for hsp70.
Περιγραφή
Λέξεις-κλειδιά
Animals, Carrier Proteins/genetics/*metabolism, Cell Nucleus/metabolism, Cells, Cultured, DNA, Complementary/isolation & purification, HSC70 Heat-Shock Proteins, HSP40 Heat-Shock Proteins, HSP70 Heat-Shock Proteins/*metabolism, Haplorhini, Heat-Shock Proteins/genetics/*metabolism, Male, Mice, RNA, Messenger/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11874471
http://onlinelibrary.wiley.com/store/10.1046/j.1432-1033.2002.02807.x/asset/j.1432-1033.2002.02807.x.pdf?v=1&t=h2bp4a5z&s=661696463a74c5cef4f50820f5470cebe5d45432
http://onlinelibrary.wiley.com/store/10.1046/j.1432-1033.2002.02807.x/asset/j.1432-1033.2002.02807.x.pdf?v=1&t=h2bp4a5z&s=661696463a74c5cef4f50820f5470cebe5d45432
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής